Vol'kenshteĭn M V, Golovanov I B, Grenader A K, Ermakov G L
Biofizika. 1988 Nov-Dec;33(6):968-72.
After conformation analysis of a number of lidocaine-like antiarrhythmic molecules a simple model of their mode of action is suggested. It is proposed that the hydrophobic antiarrhythmic molecules after their absorption on cytoplasmic membranes concentrate due to polar interactions close to ionic channel proteins, then bind to these proteins and allosterically influence the process of ionic conductance.
在对一些利多卡因样抗心律失常分子进行构象分析后，提出了它们作用方式的一个简单模型。有人提出，疏水性抗心律失常分子在被细胞质膜吸收后，由于极性相互作用而聚集在离子通道蛋白附近，然后与这些蛋白结合，并对离子传导过程产生变构影响。
