短杆菌肽A类似物：色氨酸被萘丙氨酸取代的影响。
Gramicidin A analogs: influence of the substitution of the tryptophans by naphthylalanines.
作者信息
Daumas P, Heitz F, Ranjalahy-Rasoloarijao L, Lazaro R
机构信息
Laboratoire de Physico-Chimie des Systèmes Polyphasés, CNRS UA330, Montpellier, France.
出版信息
Biochimie. 1989 Jan;71(1):77-81. doi: 10.1016/0300-9084(89)90135-1.
PMID:2470419
Abstract
The synthesis of 4 linear gramicidins bearing both polar and non-polar aromatic side chains is described. From the single channels data, it appears that the relative positions of these residues has little or no influence on the conductance and that this conductance is governed mainly by the number of tryptophan residues. It is also shown that the effect of the bulkiness of the apolar aromatic side chain can be neglected.
摘要
本文描述了4种带有极性和非极性芳香侧链的线性短杆菌肽的合成。从单通道数据来看，这些残基的相对位置对电导率几乎没有影响，且这种电导率主要由色氨酸残基的数量决定。研究还表明，非极性芳香侧链的体积效应可以忽略不计。
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