Abdullaev F I, Allakhverdiev I A, Mamedova G R
Biokhimiia. 1989 Jan;54(1):145-8.
The effect of selenium-containing compounds on RNA synthesis in rat liver cells was studied in vivo. All the selenium derivatives under study inhibited the rRNA synthesis in liver cells. The most potent inhibiting effect was exerted by sodium selenite. It was shown that in a cell-free system of RNA biosynthesis sodium selenite selectively inhibited the activity of RNA-polymerase I in isolated nuclei and purified enzyme preparations of normal and tumour cells. A feasible mechanism of inhibition of the RNA-polymerase I activity by selenium and a hypothesis on the anticarcinogenic effect of selenium are postulated.
在体内研究了含硒化合物对大鼠肝细胞RNA合成的影响。所研究的所有硒衍生物均抑制肝细胞中的rRNA合成。亚硒酸钠的抑制作用最强。结果表明，在RNA生物合成的无细胞体系中，亚硒酸钠选择性抑制正常细胞和肿瘤细胞分离细胞核及纯化酶制剂中RNA聚合酶I的活性。推测了硒抑制RNA聚合酶I活性的可行机制以及关于硒抗癌作用的假说。
