• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
[The histamine-liberating action of polymyxin B and its analogs].[多粘菌素B及其类似物的组胺释放作用]
Biull Eksp Biol Med. 1989 Apr;107(4):447-9.
2
Relationship between structure and histamine releasing action of polymyxin B and its analogues.
Agents Actions. 1990 Apr;30(1-2):153-6. doi: 10.1007/BF01969025.
3
Effect of polyethyleneglycol (PEG) on spontaneous and polymyxin B-induced histamine release from rat peritoneal mast cells.聚乙二醇（PEG）对大鼠腹膜肥大细胞自发释放和多粘菌素B诱导释放组胺的影响。
Cell Biophys. 1982 Dec;4(4):245-52. doi: 10.1007/BF02788311.
4
[Role of calcium and temperature in the histamine liberation induced by polymyxin B].
Alergia. 1982 Jul;29(3):91-7.
5
Autonomic block, cardiovascular depression and histamine release produced by polymyxin B in the cat.多粘菌素B在猫体内引起的自主神经阻滞、心血管抑制及组胺释放
Can Anaesth Soc J. 1979 May;26(3):196-200. doi: 10.1007/BF03006981.
6
Some studies on the release of histamine from mast cells treated with polymyxin.关于用多粘菌素处理肥大细胞后组胺释放的一些研究。
Agents Actions. 1984 Apr;14(3-4):379-85. doi: 10.1007/BF01973833.
7
The effect of polymyxin B and some mast-cell constituents on mucosal mast cells in the duodenum of the rat.
Cell Tissue Res. 1981;214(2):239-46. doi: 10.1007/BF00249208.
8
Effects of BP 400, an antiamine, on skin histamine and polymyxin B induced wealing.
Acta Allergol. 1968 Sep;23(3):282-6. doi: 10.1111/j.1398-9995.1968.tb04060.x.
9
In vivo inhibition of polymyxin B-induced hypotension: evidence of beta-adrenergic inhibitory activity on rat mast cells.
Gen Pharmacol. 1986;17(5):615-8. doi: 10.1016/0306-3623(86)90105-9.
10
Mast cell restoration. A study of the rat peritoneal mast cells after depletion with polymyxin B.肥大细胞的恢复。多粘菌素B耗竭后大鼠腹膜肥大细胞的研究。
Int Arch Allergy Appl Immunol. 1981;65(3):278-90.

引用本文的文献

1
Ligands and Signaling of Mas-Related G Protein-Coupled Receptor-X2 in Mast Cell Activation.Mas 相关 G 蛋白偶联受体 X2 的配体和信号转导在肥大细胞活化中的作用。
Rev Physiol Biochem Pharmacol. 2021;179:139-188. doi: 10.1007/112_2020_53.

[多粘菌素B及其类似物的组胺释放作用]

[The histamine-liberating action of polymyxin B and its analogs].

作者信息

Bairamashvili D I, Voĭtenko V G, Gushchin I S, Zinchenko A A, Miroshnikov A I

出版信息

Biull Eksp Biol Med. 1989 Apr;107(4):447-9.

PMID:2470441
Abstract

Histamine-releasing effect of polymyxin B1 and its deacylated analogues has been studied on purified rat mast cells. The structure-activity analysis showed that cyclic peptide fragment and acyl residue of molecule of polymyxin plays an important role in histamine-releasing activity. Histamine release, induced by polymyxin B1 and its analogue was blocked by metabolic inhibitor antimycin A. Preincubation of polymyxin B1 with lipopolysaccharide inhibits in dose-dependent manner polymyxin-induced histamine secretion from rat mast cells.

摘要

已在纯化的大鼠肥大细胞上研究了多粘菌素B1及其去酰化类似物的组胺释放作用。结构-活性分析表明，多粘菌素分子的环肽片段和酰基残基在组胺释放活性中起重要作用。多粘菌素B1及其类似物诱导的组胺释放被代谢抑制剂抗霉素A阻断。多粘菌素B1与脂多糖预孵育以剂量依赖性方式抑制多粘菌素诱导的大鼠肥大细胞组胺分泌。