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In vivo inhibition of polymyxin B-induced hypotension: evidence of beta-adrenergic inhibitory activity on rat mast cells.

作者信息

Botana L M, Orallo F, Espinosa J, Calleja J M

出版信息

Gen Pharmacol. 1986;17(5):615-8. doi: 10.1016/0306-3623(86)90105-9.

DOI:10.1016/0306-3623(86)90105-9
PMID:2430859
Abstract

In vitro, rat mast cells show a dose-inhibition profile when stimulated with compound 48/80 in the presence of isoprenaline. Isoprenaline-induced inhibition is stereoselective at low concentrations, being greater on pleural mast cells. In vitro, polymyxin B (0.02-0.05 mg/kg) induces a marked hypotension and slow heart rate, but not tachyphylaxis. Both effects were not suppressed in the presence of isoprenaline (with short half-life in vivo), but orciprenaline does induce a clear inhibition of Polymyxin B-induced hypotension, which correlates well with heart rate.

摘要

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