Povelones Megan L
Department of Biology, Penn State Brandywine, Media, PA, USA.
Mol Biochem Parasitol. 2014 Aug;196(1):53-60. doi: 10.1016/j.molbiopara.2014.03.008. Epub 2014 Apr 4.
The mitochondrial genome of kinetoplastids, called kinetoplast DNA (kDNA) is a complex structure that must be faithfully duplicated exactly once per cell cycle. Despite many years of thorough investigation into the kDNA replication mechanism, many of the molecular details of the later stages of the process, particularly kDNA division and segregation, remain mysterious. In addition, perturbation of several cellular activities, some only indirectly related to kDNA, can lead to asymmetric kDNA division and other segregation defects. This review will examine unifying features and possible explanations for these phenotypes in the context of current models for kDNA division and segregation.
动质体的线粒体基因组，称为动质体DNA（kDNA），是一种复杂的结构，每个细胞周期必须精确复制一次。尽管对kDNA复制机制进行了多年深入研究，但该过程后期的许多分子细节，尤其是kDNA的分裂和分离，仍然神秘莫测。此外，一些细胞活动的扰动，有些仅与kDNA间接相关，可导致kDNA不对称分裂和其他分离缺陷。本综述将在当前kDNA分裂和分离模型的背景下，研究这些表型的统一特征和可能的解释。
