Murakami S, Kubota Y, Kito S, Shimada S, Takagi H, Wu J Y, Inagaki S
Third Department of Internal Medicine, Hiroshima University School of Medicine, Japan.
Brain Res. 1989 Apr 24;485(2):403-6. doi: 10.1016/0006-8993(89)90586-6.
The coexistence of substance P- and glutamic acid decarboxylase-like immunoreactivity in cell bodies was investigated in the entopeduncular neurons of the rat by the double-immunofluorescence method using species-specific antibodies. Over half of the substance P-like immunoreactive cells were GABAergic. Double-labeled neurons were generally seen in the rostral to the middle region of the entopeduncular nucleus. Since the rostral portion of the entopeduncular nucleus mainly projects to the lateral habenular nucleus, it is suggested that double-labeled neurons in the entopeduncular nucleus largely project to the lateral habenular nucleus which is involved in the limbic system.
采用种属特异性抗体，通过双免疫荧光法研究了大鼠内苍白球神经元胞体中P物质样免疫反应性和谷氨酸脱羧酶样免疫反应性的共存情况。超过半数的P物质样免疫反应性细胞是γ-氨基丁酸能的。双标记神经元通常见于内苍白球核嘴侧至中部区域。由于内苍白球核的嘴侧部分主要投射至外侧缰核，提示内苍白球核中的双标记神经元大部分投射至参与边缘系统的外侧缰核。
