Centre National de la Recherche Scientifique UMR 5227, Bordeaux Institute of Neuroscience, Université Victor-Segalen Bordeaux 2 Bordeaux, France.
Front Neuroanat. 2010 Sep 14;4. doi: 10.3389/fnana.2010.00131. eCollection 2010.
Involuntary movements or dyskinesia, represent a debilitating complication of levodopa therapy for Parkinson's disease. Dyskinesia is, ultimately, experienced by the vast majority of the patients. Despite the importance of this problem, little was known about the cause of dyskinesia, a situation that has dramatically evolved in the last few years with a focus upon the molecular and signaling changes induced by chronic levodopa treatment. Departing from this, we here review the progress made in functional anatomy and neuroimaging that have had a tremendous impact on our understanding of the anatomo-functional organization of the basal ganglia in Parkinsonism and dyskinetic states, notably the demonstration that dyskinesia are linked to a pathological processing of limbic and cognitive information.
不自主运动或运动障碍是左旋多巴治疗帕金森病的一种使人虚弱的并发症。运动障碍最终会影响绝大多数患者。尽管这个问题很重要，但人们对运动障碍的原因知之甚少，而近年来，随着对慢性左旋多巴治疗引起的分子和信号变化的关注，这种情况发生了巨大变化。在此基础上，我们回顾了在功能解剖学和神经影像学方面取得的进展，这些进展极大地促进了我们对帕金森病和运动障碍状态下基底神经节的解剖功能组织的理解，特别是证明运动障碍与边缘和认知信息的病理性处理有关。
