Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC 20057, USA.
Cancers (Basel). 2014 Apr 3;6(2):771-95. doi: 10.3390/cancers6020771.
The breast cancer susceptibility gene 1 (BRCA1) has been well established as a tumor suppressor and functions primarily by maintaining genome integrity. Genome stability is compromised when cells are exposed to oxidative stress. Increasing evidence suggests that BRCA1 regulates oxidative stress and this may be another mechanism in preventing carcinogenesis in normal cells. Oxidative stress caused by reactive oxygen species (ROS) is implicated in carcinogenesis and is used strategically to treat human cancer. Thus, it is essential to understand the function of BRCA1 in oxidative stress regulation. In this review, we briefly summarize BRCA1's many binding partners and mechanisms, and discuss data supporting the function of BRCA1 in oxidative stress regulation. Finally, we consider its significance in prevention and/or treatment of BRCA1-related cancers.
乳腺癌易感基因 1(BRCA1)已被充分确认为一种肿瘤抑制基因,主要通过维持基因组完整性发挥作用。当细胞暴露于氧化应激时,基因组稳定性就会受到损害。越来越多的证据表明,BRCA1 可以调节氧化应激,这可能是预防正常细胞癌变的另一种机制。活性氧(ROS)引起的氧化应激与癌变有关,并被策略性地用于治疗人类癌症。因此,了解 BRCA1 在氧化应激调节中的功能至关重要。在这篇综述中,我们简要总结了 BRCA1 的许多结合伙伴和机制,并讨论了支持 BRCA1 在氧化应激调节中发挥作用的数据。最后,我们考虑了它在预防和/或治疗 BRCA1 相关癌症方面的意义。