Susan Lehman-Cullman Laboratory for Cancer Research, Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA.
Genes (Basel). 2013 Jul 1;4(3):334-57. doi: 10.3390/genes4030334.
The Eph family of receptor tyrosine kinases (RTKs) has been implicated in the regulation of many aspects of mammalian development. Recent analyses have revealed that the EphA2 receptor is a key modulator for a wide variety of cellular functions. This review focuses on the roles of EphA2 in both development and disease.
Eph 家族的受体酪氨酸激酶 (RTKs) 参与了哺乳动物发育的许多方面的调节。最近的分析表明，EphA2 受体是多种细胞功能的关键调节剂。本文重点介绍 EphA2 在发育和疾病中的作用。
