Tabrizi Reza, Eftekharian Hamidreza, Pourdanesh Freydoun, Khaghaninejad Mohammad Saleh
From the *Department of Maxillofacial Surgery, Shahidbeheshti University of Medical Science, Tehran; †Department of Anesthesiology, Shiraz University of Medical Science, Shiraz; ‡Department of Maxillofacial Surgery, Shahidbeheshti University of Medical Sciences, Tehran; and §Department of Maxillofacial Surgery, Shiraz University of Medical Science, Shiraz, Iran.
J Craniofac Surg. 2014 May;25(3):1101-3. doi: 10.1097/SCS.0000000000000660.
This uni-blind randomized clinical trial study investigated the effect of clonidine premedication on preoperative blood loss during open rhinoplasty. The subjects were randomly divided into 2 groups. The members of the first group received oral clonidine as a single dose (0.2 mg) 2 hours before the induction of general anesthesia, whereas the members of the second group received a placebo. All subjects underwent open rhinoplasty without septoplasty. One anesthetic protocol was followed for all subjects. Variable factors include the subjects' weight, age, sex, and blood pressure during the surgery as well as blood loss during rhinoplasty. Group 1 consisted of 22 women and 11 men, whereas group 2 was composed of 16 women and 17 men. The mean for blood loss amounted to 68.03 ± 22.49 mL for group 1 and 132.12 ± 78.53 mL for group 2. An assessment demonstrated a significant difference in blood loss between the 2 groups (P < 0.001.) Oral clonidine premedication thus may decrease preoperative bleeding during open rhinoplasty.
这项单盲随机临床试验研究了可乐定术前用药对开放式鼻整形术期间术前失血量的影响。受试者被随机分为两组。第一组成员在全身麻醉诱导前2小时接受口服可乐定单剂量（0.2毫克），而第二组成员接受安慰剂。所有受试者均接受开放式鼻整形术，未行鼻中隔成形术。所有受试者遵循一种麻醉方案。可变因素包括受试者的体重、年龄、性别、手术期间的血压以及鼻整形术期间的失血量。第一组由22名女性和11名男性组成，而第二组由16名女性和17名男性组成。第一组的平均失血量为68.03±22.49毫升，第二组为132.12±78.53毫升。评估表明两组之间的失血量存在显著差异（P<0.001）。因此，口服可乐定术前用药可能会减少开放式鼻整形术期间的术前出血。
