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鼻整形术中减少麻醉药物使用:最新的叙述性综述与方案

Minimizing Narcotic Use in Rhinoplasty: An Updated Narrative Review and Protocol.

作者信息

Cheung Madison Mai-Lan, Shah Anil

机构信息

College of Medicine at Rockford, University of Illinois Chicago, Rockford, IL 61107, USA.

Department of Surgery, Section of Otolaryngology, University of Chicago, Chicago, IL 60637, USA.

出版信息

Life (Basel). 2024 Oct 7;14(10):1272. doi: 10.3390/life14101272.

Abstract

Opioids are commonly used to reduce pain after surgery; however, there are severe side effects and complications associated with opioid use, with addiction being of particular concern. Recent practice has shifted to reduce opioid consumption in surgery, although a specific protocol for rhinoplasty is still in progress. This paper aims to expand on the protocol previously established by the senior author based on updated evidence and details. This was accomplished by first high-lighting and summarizing analgesic agents with known opioid-reducing effects in the surgical field, with a particular focus on rhinoplasty, then compiling these analgesic options into a recommended protocol based on the most effective timing of administration (preoperative, intraoperative, postoperative). The senior author's previous article on the subject was referenced to compile a list of analgesic agents of importance. Each analgesic agent was then searched in PubMed in conjunction with "rhinoplasty" or "opioid sparing" to find relevant primary sources and systematic reviews. The preferred analgesic agents included, as follows: preoperative, 1000 mg oral acetaminophen, 200 mg of oral celecoxib twice daily for 5 days, and 1200 mg oral gabapentin; intraoperative, 0.75 μg/kg of intravenous dexmedetomidine and 1-2 mg/kg injected lidocaine with additional 2-4 mg/kg per hour or 1.5 cc total bupivacaine nerve block injected along the infraorbital area bilaterally and in the subnasal region; and postoperatively, 5 mg oral acetaminophen and 400 mg of oral celecoxib. When choosing specific analgesic agents, considerations include potential side effects, contraindications, and the drug-specific mode of administration.

摘要

阿片类药物常用于减轻术后疼痛;然而,使用阿片类药物会产生严重的副作用和并发症,成瘾问题尤其令人担忧。尽管鼻整形术的具体方案仍在制定中,但近期的做法已转向减少手术中阿片类药物的使用。本文旨在根据最新证据和细节,对资深作者先前制定的方案进行扩展。首先,通过突出和总结手术领域中已知具有减少阿片类药物作用的镇痛剂来实现这一目标,特别关注鼻整形术,然后根据最有效的给药时间(术前、术中、术后)将这些镇痛选择汇编成推荐方案。参考了资深作者之前关于该主题的文章,以编制一份重要镇痛剂清单。然后在PubMed中结合“鼻整形术”或“阿片类药物节省”搜索每种镇痛剂,以找到相关的原始资料和系统评价。首选的镇痛剂如下:术前,口服对乙酰氨基酚1000毫克,口服塞来昔布200毫克,每日两次,共5天,口服加巴喷丁1200毫克;术中,静脉注射右美托咪定0.75微克/千克和注射利多卡因1 - 2毫克/千克,每小时额外追加2 - 4毫克/千克,或沿双侧眶下区域和鼻下区域双侧注射总量为1.5毫升的布比卡因神经阻滞;术后,口服对乙酰氨基酚5毫克和口服塞来昔布400毫克。选择特定的镇痛剂时,需要考虑潜在的副作用、禁忌症和药物特定的给药方式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c4e0/11509072/649db134c09b/life-14-01272-g001.jpg

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