Wound amylase estimation and the prediction of pharyngocutaneous fistulae.

Pharyngocutaneous fistula is a common complication after major head and neck surgery. In this study it was possible to predict fistula formation as early as the second postoperative day, using serial measurements of the amylase concentration in wound drainage. Wound amylase estimation may be used to help avoid major pharyngocutaneous fistulae by providing an 'early warning' and allowing modification of the postoperative feeding regimen in certain situations.