Hegedüs K, Molnár P
Department of Neurology and Psychiatry, University Medical School of Debrecen, Hungary.
Clin Neuropathol. 1989 Mar-Apr;8(2):92-7.
The results of post mortem histological studies on the major intracranial arteries from 150 individuals, whose age varied from one day to 80 years are reported. Patients with specific vascular diseases or severe atherosclerosis were excluded. The work resulted in the following conclusions: 1) The existence of 3 types of so-called pseudoelastic fibers can be revealed by light microscopic staining procedures. All of them share some staining characteristics of true elastic fibers. Types 1 and 2 also stain to a certain extent like reticulin fibers. Type 3 pseudoelastic fibers resemble collagen fibers in some of their staining qualities. 2) At birth the internal elastic lamina (IEL) consists of true elastic fibers and type 1 pseudoelastic fibers. 3) These 2 fibers are present throughout life, though from the age of two years, type 2 pseudoelastic fibers become additional but permanent components of IEL. 4) Aging is accompanied by the appearance of collagen fibers. The relative proportion of different fibers within the IEL seems to follow a consistent sequence of changes. 5) The appearance of type 3 pseudoelastic and/or collagen fibers indicates abnormality since it is inevitably associated with loss of elasticity of the vessel wall.
报告了对150名年龄从1天到80岁个体的主要颅内动脉进行尸检组织学研究的结果。排除患有特定血管疾病或严重动脉粥样硬化的患者。这项研究得出了以下结论：1）通过光学显微镜染色程序可发现存在3种所谓的假弹性纤维。它们都具有一些真弹性纤维的染色特征。1型和2型在一定程度上也像网状纤维一样染色。3型假弹性纤维在某些染色特性上类似于胶原纤维。2）出生时，内弹性膜（IEL）由真弹性纤维和1型假弹性纤维组成。3）这两种纤维终生存在，不过从两岁起，2型假弹性纤维成为IEL的额外但永久性成分。4）衰老伴随着胶原纤维的出现。IEL内不同纤维的相对比例似乎遵循一致的变化顺序。5）3型假弹性纤维和/或胶原纤维的出现表明异常，因为它不可避免地与血管壁弹性丧失相关。
