Sims F H
Artery. 1985;13(3):127-43.
The internal elastic lamina (iel.) of the anterior descending branch of the left coronary artery, and the internal mammary artery, were studied in 166 unselected subjects of different ages and races. The coronary artery showed substantial defects in the iel. even in the first few years of life, while the iel. of the mammary artery showed only minimal defects in all age groups. The defects in the iel. were associated with the presence of medial cells in the intima, and the thickness of the intima was correlated with the magnitude of the defects in the iel. (Correlation coefficient 0.95 for the coronary artery and 0.80 for the mammary artery). Small arteries involved in chronic inflammatory or neoplastic disease showed a similar relationship if the vessel were present in an edematous area. These vessels which do not usually show intimal thickening, displayed a thickened intima in the vicinity of defects of the iel. It is suggested that the pronounced difference in the incidence of arteriosclerosis between the coronary and internal mammary arteries is related to these defects in the internal elastic lamina.
对166名不同年龄和种族的未经筛选的受试者的左冠状动脉前降支的内弹性膜（iel.）和乳内动脉进行了研究。冠状动脉即使在生命的最初几年，其iel.也显示出明显的缺损，而乳内动脉的iel.在所有年龄组中仅显示出最小的缺损。iel.的缺损与内膜中中层细胞的存在有关，并且内膜的厚度与iel.的缺损程度相关（冠状动脉的相关系数为0.95，乳内动脉的相关系数为0.80）。如果血管存在于水肿区域，参与慢性炎症或肿瘤性疾病的小动脉也显示出类似的关系。这些通常不显示内膜增厚的血管，在iel.缺损附近显示出内膜增厚。提示冠状动脉和乳内动脉之间动脉粥样硬化发生率的显著差异与内弹性膜的这些缺损有关。
