一种可预防乳腺癌的甲胎蛋白活性位点肽类似物的研发。

Development of an active site peptide analog of α-fetoprotein that prevents breast cancer.

作者信息

Jacobson Herbert I, Andersen Thomas T, Bennett James A

机构信息

Authors' Affiliations: Department of Obstetrics and Gynecology, Center for Cardiovascular Sciences, and Center for Immunology and Microbial Diseases, Albany Medical College, Albany, NYAuthors' Affiliations: Department of Obstetrics and Gynecology, Center for Cardiovascular Sciences, and Center for Immunology and Microbial Diseases, Albany Medical College, Albany, NY.

Authors' Affiliations: Department of Obstetrics and Gynecology, Center for Cardiovascular Sciences, and Center for Immunology and Microbial Diseases, Albany Medical College, Albany, NY

出版信息

Cancer Prev Res (Phila). 2014 Jun;7(6):565-73. doi: 10.1158/1940-6207.CAPR-13-0405. Epub 2014 Apr 4.

DOI:10.1158/1940-6207.CAPR-13-0405

PMID:24706695

Abstract

Epidemiologic studies associate elevated maternal serum levels of α-fetoprotein (AFP) with reduced breast cancer risk for parous women. Laboratory studies demonstrate direct anti-breast cancer activity of AFP. Here, we review the development of a small cyclic peptide that is an active site analog of AFP, referred to as AFPep, which is composed exclusively of amino acids, is orally active, has no discernable toxicity, and is effective for the treatment and prevention of breast cancer in animal models.

摘要

流行病学研究表明，产妇血清中α-甲胎蛋白（AFP）水平升高与经产妇患乳腺癌的风险降低有关。实验室研究证明了AFP具有直接的抗乳腺癌活性。在此，我们综述了一种小环肽的研发情况，该小环肽是AFP的活性位点类似物，称为AFPep，它仅由氨基酸组成，口服有效，无明显毒性，并且在动物模型中对乳腺癌的治疗和预防有效。