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甲胎蛋白（AFP）在当代肿瘤学中的作用：从诊断生物标志物到抗癌药物。

The Role of Alpha-Fetoprotein (AFP) in Contemporary Oncology: The Path from a Diagnostic Biomarker to an Anticancer Drug.

机构信息

PreMediCare New Med Medical Center, ul. Czarna Rola 21, 61-625 Poznań, Poland.

Department of Perinatology and Gynecology, Poznan University of Medical Sciences, 60-535 Poznań, Poland.

出版信息

Int J Mol Sci. 2023 Jan 28;24(3):2539. doi: 10.3390/ijms24032539.

DOI:10.3390/ijms24032539
PMID:36768863
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9917199/
Abstract

This article presents contemporary opinion on the role of alpha-fetoprotein in oncologic diagnostics and treatment. This role stretches far beyond the already known one-that of the biomarker of hepatocellular carcinoma. The turn of the 20th and 21st centuries saw a significant increase in knowledge about the fundamental role of AFP in the neoplastic processes, and in the induction of features of malignance and drug resistance of hepatocellular carcinoma. The impact of AFP on the creation of an immunosuppressive environment for the developing tumor was identified, giving rise to attempts at immunotherapy. The paper presents current and prospective therapies using AFP and its derivatives and the gene therapy options. We directed our attention to both the benefits and risks associated with the use of AFP in oncologic therapy.

摘要

本文介绍了甲胎蛋白在肿瘤诊断和治疗中的作用的现代观点。这种作用远远超出了已经众所周知的肝癌生物标志物的作用。20 世纪和 21 世纪之交，人们对 AFP 在肿瘤发生过程中的基本作用以及诱导肝癌恶性和耐药特征方面的知识有了显著的提高。人们发现 AFP 对为发展中的肿瘤创造免疫抑制环境有影响，从而引发了免疫治疗的尝试。本文介绍了使用 AFP 及其衍生物的当前和未来疗法以及基因治疗选择。我们既关注了 AFP 在肿瘤治疗中的应用所带来的益处，也关注了其相关风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8770/9917199/31b3e6f8bec2/ijms-24-02539-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8770/9917199/77569648aa7c/ijms-24-02539-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8770/9917199/65e72dc7a569/ijms-24-02539-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8770/9917199/538f8852c115/ijms-24-02539-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8770/9917199/31b3e6f8bec2/ijms-24-02539-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8770/9917199/77569648aa7c/ijms-24-02539-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8770/9917199/65e72dc7a569/ijms-24-02539-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8770/9917199/538f8852c115/ijms-24-02539-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8770/9917199/31b3e6f8bec2/ijms-24-02539-g004.jpg

相似文献

[1]
The Role of Alpha-Fetoprotein (AFP) in Contemporary Oncology: The Path from a Diagnostic Biomarker to an Anticancer Drug.

Int J Mol Sci. 2023-1-28

[2]
Sorafenib and hepatocellular carcinoma: is alpha-fetoprotein a biomarker predictive of tumor biology and primary resistance?

Future Oncol. 2021-9

[3]
The Landscape Of Alpha Fetoprotein In Hepatocellular Carcinoma: Where Are We?

Int J Biol Sci. 2022

[4]
Current Status and Perspective Biomarkers in AFP Negative HCC: Towards Screening for and Diagnosing Hepatocellular Carcinoma at an Earlier Stage.

Pathol Oncol Res. 2020-4

[5]
PIVKA-II serves as a potential biomarker that complements AFP for the diagnosis of hepatocellular carcinoma.

BMC Cancer. 2021-4-13

[6]
Alpha-fetoprotein, protein induced by vitamin K absence or antagonist-II, lens culinaris agglutinin-reactive fraction of alpha-fetoprotein alone and in combination for early detection of hepatocellular carcinoma from nonalcoholic fatty liver disease: A multicenter analysis.

Hepatobiliary Pancreat Dis Int. 2022-12

[7]
Homocysteine: A novel prognostic biomarker in liver transplantation for alpha-fetoprotein- negative hepatocellular carcinoma.

Cancer Biomark. 2020

[8]
A prospective study of blood alpha-fetoprotein messenger RNA as a predictor of hepatocellular carcinoma in patients with cirrhosis.

J Viral Hepat. 2003-11

[9]
Alpha-fetoprotein is a biomarker of unfolded protein response and altered proteostasis in hepatocellular carcinoma cells exposed to sorafenib.

Cancer Lett. 2015-11-3

[10]
Diagnostic value of alpha-fetoprotein, agglutinin-reactive alpha-fetoprotein, and des-gamma-carboxyprothrombin in hepatitis B virus-related hepatocellular carcinoma.

J Int Med Res. 2020-3

引用本文的文献

[1]
Alpha-fetoprotein: A Multifaceted Player in Cancer Biology.

Euroasian J Hepatogastroenterol. 2025

[2]
Analysis of factors influencing tumor volume doubling time in hepatocellular carcinoma and its predictive value for progression-free survival.

Sci Rep. 2025-7-16

[3]
Exploring the Multifunctional Role of Alpha-Fetoprotein in Cancer Progression: Implications for Targeted Therapy in Hepatocellular Carcinoma and Beyond.

Int J Mol Sci. 2025-5-19

[4]
Emerging Multifunctional Carbon-Nanomaterial-Based Biosensors for Cancer Diagnosis.

Small Sci. 2024-1-22

[5]
Recent Advances in SAW Sensors for Detection of Cancer Biomarkers.

Biosensors (Basel). 2025-2-5

[6]
Alpha-fetoprotein-to-PIVKA-II ratio as a potential biomarker for hepatocellular carcinoma differentiation, imaging characteristics, and patient survival.

Transl Cancer Res. 2024-11-30

[7]
Pediatric Ovarian Yolk Sac Tumor Mimicking Appendicitis: A Case Report From a Low-Resource Setting.

Clin Case Rep. 2024-12-15

[8]
Alpha-fetoprotein, glypican-3, and kininogen-1 as biomarkers for the diagnosis of hepatocellular carcinoma.

Int J Clin Exp Pathol. 2024-11-15

[9]
In-silico studies on evaluating the liver-protective effectiveness of a polyherbal formulation in preventing hepatocellular carcinoma progression.

In Silico Pharmacol. 2024-11-19

[10]
Beyond the WHO 2020 Classification of Female Genital Tumors: Types of Endometrial Cancer: A Pathological and Molecular Focus on Challenging Rare Variants.

Int J Mol Sci. 2024-9-25

本文引用的文献

[1]
Real-life multi-center retrospective analysis on nivolumab in difficult-to-treat patients with advanced hepatocellular carcinoma.

World J Hepatol. 2022-8-27

[2]
Cyclic Peptides for the Treatment of Cancers: A Review.

Molecules. 2022-7-11

[3]
Preparation of NIR-Responsive Gold Nanocages as Efficient Carrier for Controlling Release of EGCG in Anticancer Application.

Front Chem. 2022-6-2

[4]
Immunomodulatory impact of α-fetoprotein.

Trends Immunol. 2022-6

[5]
Alpha-fetoprotein (AFP) - new aspects of a well-known marker in perinatology.

Ginekol Pol. 2022

[6]
Comprehensive clinicopathologic study of alpha fetoprotein-expression in a large cohort of patients with hepatocellular carcinoma.

Int J Cancer. 2022-3-15

[7]
Role of the alpha-fetoprotein response in immune checkpoint inhibitor-based treatment of patients with hepatocellular carcinoma.

J Cancer Res Clin Oncol. 2022-8

[8]
Alpha-Fetoprotein- and CD40Ligand-Expressing Dendritic Cells for Immunotherapy of Hepatocellular Carcinoma.

Cancers (Basel). 2021-7-5

[9]
AFP-Inhibiting Fragments for Drug Delivery: The Promise and Challenges of Targeting Therapeutics to Cancers.

Front Cell Dev Biol. 2021-4-8

[10]
PLGA nanoparticles containing α-fetoprotein siRNA induce apoptosis and enhance the cytotoxic effects of doxorubicin in human liver cancer cell line.

Biochem Biophys Res Commun. 2021-5-14

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