Pilpel N, Otuyemi S O, Kurup T R
J Pharm Pharmacol. 1978 Apr;30(4):214-9. doi: 10.1111/j.2042-7158.1978.tb13207.x.
A study has been made of the effects produced on the disintegration and dissolution times of chloroquine phosphate tablets by varying their moisture and starch contents and the distribution of the starch in the formulation. 3 to 5% w/w of moisture produces a maximum in the disintegration and dissolution times. Starch added externally as a powder acts only as a disintegrating agent for the tablets, but starch added internally as a paste during granulation acts both as a binding agent and a disintegrant.
研究了改变磷酸氯喹片的水分和淀粉含量以及淀粉在制剂中的分布对其崩解和溶解时间的影响。3%至5%（w/w）的水分会使崩解和溶解时间达到最大值。外部添加的粉末状淀粉仅作为片剂的崩解剂，但制粒过程中作为糊剂内部添加的淀粉兼具粘合剂和崩解剂的作用。
