2012年药物化学奖获奖致辞。探寻大麻素之路：个人视角。
2012 Division of medicinal chemistry award address. Trekking the cannabinoid road: a personal perspective.
作者信息
Makriyannis Alexandros
机构信息
Center for Drug Discovery and Departments of Chemistry and Chemical Biology and Pharmaceutical Sciences, Northeastern University , 360 Huntington Avenue, Boston, Massachusetts 02115, United States.
出版信息
J Med Chem. 2014 May 22;57(10):3891-911. doi: 10.1021/jm500220s. Epub 2014 May 1.
My involvement with the field of cannabinoids spans close to 3 decades and covers a major part of my scientific career. It also reflects the robust progress in this initially largely unexplored area of biology. During this period of time, I have witnessed the growth of modern cannabinoid biology, starting from the discovery of its two receptors and followed by the characterization of its endogenous ligands and the identification of the enzyme systems involved in their biosynthesis and biotransformation. I was fortunate enough to start at the beginning of this new era and participate in a number of the new discoveries. It has been a very exciting journey. With coverage of some key aspects of my work during this period of "modern cannabinoid research," this Award Address, in part historical, intends to give an account of how the field grew, the key discoveries, and the most promising directions for the future.
我涉足大麻素领域已近30年，这占据了我科研生涯的大部分时间。这也反映了这个最初在很大程度上未被探索的生物学领域取得的蓬勃进展。在此期间，我见证了现代大麻素生物学的发展，从其两种受体的发现开始，接着是对内源性配体的表征以及参与其生物合成和生物转化的酶系统的鉴定。我很幸运能在这个新时代伊始就参与其中，并见证了许多新发现。这是一段非常激动人心的历程。在本次获奖演讲中，我将涵盖“现代大麻素研究”这段时期我工作的一些关键方面，部分内容具有历史意义，旨在讲述该领域是如何发展的、关键发现以及未来最有前景的方向。
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