Deng Jianping, Xue Yao, Wang Yaping, Chen Jing, Li Jie, Lu Qin, Wang Meilin, Tong Na, Zhang Zhengdong, Fang Yongjun
Department of Hematology and Oncology, Nanjing Children's Hospital Affiliated to Nanjing Medical University , Nanjing , China.
Leuk Lymphoma. 2015 Jan;56(1):175-8. doi: 10.3109/10428194.2014.910775. Epub 2014 Jun 16.
Acute lymphoblastic leukemia (ALL) is a clonal hematologic disease, and is the most common cause of childhood malignancy. Recently, a new locus was identified at 10p12.31-12.2 through a genome-wide association study (GWAS) that included racially and ethnically diverse populations. We conducted a replication study with 570 cases of ALL and 673 cancer-free controls to validated the association of this locus with ALL susceptibility in a Chinese population. The results of our study confirmed that the 10p12.31-12.2 locus was linked to childhood ALL susceptibility in the Chinese population. Interestingly, we also found that the single nucleotide polymorphisms (SNPs) in this locus had a larger effect on susceptibility to high-risk ALL than on susceptibility to low-risk ALL.
急性淋巴细胞白血病（ALL）是一种克隆性血液系统疾病，也是儿童恶性肿瘤最常见的病因。最近，通过一项纳入了不同种族和民族人群的全基因组关联研究（GWAS），在10p12.31 - 12.2区域发现了一个新的基因座。我们开展了一项重复研究，纳入570例ALL病例和673例无癌对照，以验证该基因座与中国人群ALL易感性的关联。我们的研究结果证实，10p12.31 - 12.2基因座与中国人群儿童ALL易感性相关。有趣的是，我们还发现该基因座中的单核苷酸多态性（SNP）对高危ALL易感性的影响比对低危ALL易感性的影响更大。
