注射到哺乳动物大脑中的白细胞介素-1会刺激星形胶质细胞增生和血管生成。
Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization.
作者信息
Giulian D, Woodward J, Young D G, Krebs J F, Lachman L B
机构信息
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030.
出版信息
J Neurosci. 1988 Jul;8(7):2485-90. doi: 10.1523/JNEUROSCI.08-07-02485.1988.
Abstract
Interleukin-1 (IL-1), a protein produced by mononuclear phagocytes, helps to initiate the inflammatory response through its action upon a diverse population of cells. Recently this immunomodulator has been detected at sites of traumatized brain. As reported here, recombinant forms of IL-1 injected into the cerebral cortex of adult rats elicit not only astrogliosis but also new blood vessel growth. These responses are typical of brain injury and suggest that IL-1-secreting inflammatory cells may mediate wound healing in the CNS.
摘要
白细胞介素-1（IL-1）是一种由单核吞噬细胞产生的蛋白质，它通过作用于多种细胞来帮助启动炎症反应。最近，在脑外伤部位检测到了这种免疫调节剂。如本文所报道，将重组形式的IL-1注入成年大鼠的大脑皮层，不仅会引发星形胶质细胞增生，还会促进新血管生长。这些反应是脑损伤的典型表现，表明分泌IL-1的炎症细胞可能介导中枢神经系统的伤口愈合。
相似文献
1
Interleukin-1 injected into mammalian brain stimulates astrogliosis and neovascularization.注射到哺乳动物大脑中的白细胞介素-1会刺激星形胶质细胞增生和血管生成。
J Neurosci. 1988 Jul;8(7):2485-90. doi: 10.1523/JNEUROSCI.08-07-02485.1988.
2
Interleukin-1 beta does not induce reactive astrogliosis, neovascularization or scar formation in the immature rat brain.白细胞介素-1β不会在未成熟大鼠脑中诱导反应性星形胶质细胞增生、新血管形成或瘢痕形成。
Int J Dev Neurosci. 1993 Apr;11(2):281-93. doi: 10.1016/0736-5748(93)90086-s.
3
The role of mononuclear phagocytes in wound healing after traumatic injury to adult mammalian brain.单核吞噬细胞在成年哺乳动物脑外伤后伤口愈合中的作用。
J Neurosci. 1989 Dec;9(12):4416-29. doi: 10.1523/JNEUROSCI.09-12-04416.1989.
4
Interleukin-1 beta is required for the early evolution of reactive astrogliosis following CNS lesion.白细胞介素-1β是中枢神经系统损伤后反应性星形胶质细胞增生早期演变所必需的。
J Neuropathol Exp Neurol. 2001 Oct;60(10):961-71. doi: 10.1093/jnen/60.10.961.
5
CNTF regulation of astrogliosis and the activation of microglia in the developing rat central nervous system.睫状神经营养因子对发育中大鼠中枢神经系统星形胶质细胞增生及小胶质细胞激活的调控
Brain Res. 1995 Jul 10;685(1-2):55-67. doi: 10.1016/0006-8993(95)00411-i.
6
Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines.新生小鼠大脑中的反应性星形胶质细胞增生及其受细胞因子的调节
J Neurosci. 1994 Feb;14(2):846-56. doi: 10.1523/JNEUROSCI.14-02-00846.1994.
7
Chemically induced neuronal damage and gliosis: enhanced expression of the proinflammatory chemokine, monocyte chemoattractant protein (MCP)-1, without a corresponding increase in proinflammatory cytokines(1).化学诱导的神经元损伤和胶质细胞增生：促炎趋化因子单核细胞趋化蛋白（MCP）-1表达增强，而促炎细胞因子无相应增加(1)。
Neuroscience. 2002;115(1):307-20. doi: 10.1016/s0306-4522(02)00359-7.
8
Brain-IL-1 beta triggers astrogliosis through induction of IL-6: inhibition by propranolol and IL-10.脑白细胞介素-1β通过诱导白细胞介素-6引发星形胶质细胞增生：普萘洛尔和白细胞介素-10的抑制作用
Med Sci Monit. 2004 Sep;10(9):BR325-30. Epub 2004 Aug 20.
9
The type 1 interleukin-1 receptor is essential for the efficient activation of microglia and the induction of multiple proinflammatory mediators in response to brain injury.1型白细胞介素-1受体对于小胶质细胞的有效激活以及响应脑损伤诱导多种促炎介质至关重要。
J Neurosci. 2002 Jul 15;22(14):6071-82. doi: 10.1523/JNEUROSCI.22-14-06071.2002.
10
Astrogliosis in the neonatal and adult murine brain post-trauma: elevation of inflammatory cytokines and the lack of requirement for endogenous interferon-gamma.新生和成年小鼠脑创伤后星形胶质细胞增生：炎性细胞因子升高及对内源性干扰素-γ的需求缺失
J Neurosci. 1997 May 15;17(10):3664-74. doi: 10.1523/JNEUROSCI.17-10-03664.1997.
引用本文的文献
1
Influence of Monosodium Glutamate on Astroglia of Rat Habenula.谷氨酸钠对大鼠缰核星形胶质细胞的影响。
Biomolecules. 2025 Aug 1;15(8):1111. doi: 10.3390/biom15081111.
2
Unexpectedly High and Difficult-to-Explain Regenerative Capacity in an 82-Year-Old Patient with Insulin-Requiring Type 2 Diabetes and End-Stage Renal Disease.一名患有胰岛素依赖型2型糖尿病和终末期肾病的82岁患者出现了意想不到的高且难以解释的再生能力。
J Clin Med. 2025 Apr 8;14(8):2556. doi: 10.3390/jcm14082556.
3
-mediated clonal hematopoiesis modestly improves neurological deficits and is associated with inflammation resolution in the subacute phase of experimental stroke.介导的克隆性造血适度改善神经功能缺损，并与实验性中风亚急性期的炎症消退相关。
Front Cell Neurosci. 2024 Dec 17;18:1487867. doi: 10.3389/fncel.2024.1487867. eCollection 2024.
4
Macroscopic changes in aquaporin-4 underlie blast traumatic brain injury-related impairment in glymphatic function.水通道蛋白-4 的宏观变化是爆炸创伤性脑损伤相关神经淋巴功能障碍的基础。
Brain. 2024 Jun 3;147(6):2214-2229. doi: 10.1093/brain/awae065.
5
Therapeutic effect of combination vitamin D3 and siponimod on remyelination and modulate microglia activation in cuprizone mouse model of multiple sclerosis.维生素D3与西尼莫德联合使用对多发性硬化症铜螯合剂小鼠模型中髓鞘再生及小胶质细胞激活的调节作用
Front Behav Neurosci. 2023 Jan 5;16:1068736. doi: 10.3389/fnbeh.2022.1068736. eCollection 2022.
6
The Inflammatory Response after Moderate Contusion Spinal Cord Injury: A Time Study.中度挫伤性脊髓损伤后的炎症反应：一项时间研究。
Biology (Basel). 2022 Jun 20;11(6):939. doi: 10.3390/biology11060939.
7
Developmental Neuropathology and Neurodegeneration of Down Syndrome: Current Knowledge in Humans.唐氏综合征的发育神经病理学与神经退行性变：人类的现有知识
Front Cell Dev Biol. 2022 May 23;10:877711. doi: 10.3389/fcell.2022.877711. eCollection 2022.
8
Glia-Driven Brain Circuit Refinement Is Altered by Early-Life Adversity: Behavioral Outcomes.早期生活逆境改变神经胶质细胞驱动的脑回路优化：行为结果
Front Behav Neurosci. 2021 Dec 2;15:786234. doi: 10.3389/fnbeh.2021.786234. eCollection 2021.
9
The effect of insomnia on development of Alzheimer's disease.失眠对阿尔茨海默病发展的影响。
J Neuroinflammation. 2020 Oct 6;17(1):289. doi: 10.1186/s12974-020-01960-9.
10
Interferon-Gamma and Interleukin-1Beta Enhance the Secretion of Brain-Derived Neurotrophic Factor and Promotes the Survival of Cortical Neurons in Brain Injury.干扰素-γ和白细胞介素-1β增强脑源性神经营养因子的分泌并促进脑损伤中皮质神经元的存活。
Neurosci Insights. 2020 Jul 29;15:2633105520947081. doi: 10.1177/2633105520947081. eCollection 2020.
Zotero 插件