阿多洛尔对微波诱导的大鼠心肌细胞β1-肾上腺素能受体和毒蕈碱型 2 乙酰胆碱受体表达的下调作用。
AduoLa Fuzhenglin down-regulates microwave-induced expression of β1-adrenergic receptor and muscarinic type 2 acetylcholine receptor in myocardial cells of rats.
机构信息
Beijing Institute of Radiation Medicine, Beijing 100850, China.
出版信息
Biomed Environ Sci. 2014 Mar;27(3):204-7. doi: 10.3967/bes2014.041.
This paper is aimed to study the effect of ADL on expression of β1-AR and M2-AchR in myocardial cells of rats exposed to microwave radiation. Immunohistochemistry, Western blot and image analysis were used to detect the expression of β1-AR and M2-AchR in myocardial cells at 7 and 14 d after microwave exposure. The results show that the expression level was higher in microwave exposure group and 0.75 g/(kg•d) ADL group than in sham operation group and significantly lower in 1.5 and 3.0 g/(kg•d) ADL groups than in microwave group. So we have a conclusion that the expression of β1-AR and M2-AchR is down-regulated in myocardial cells of rats exposed to microwave radiation. ADL can protect rats against microwave-induced heart tissue injury.
本论文旨在研究 ADL 对微波辐射暴露大鼠心肌细胞中β1-AR 和 M2-AchR 表达的影响。采用免疫组化、Western blot 和图像分析方法检测微波暴露后 7 和 14 d 大鼠心肌细胞中β1-AR 和 M2-AchR 的表达。结果表明，微波暴露组和 0.75 g/（kg•d）ADL 组的表达水平高于假手术组，1.5 和 3.0 g/（kg•d）ADL 组明显低于微波组。因此，我们得出结论，微波辐射可使大鼠心肌细胞中β1-AR 和 M2-AchR 的表达下调，ADL 可保护大鼠免受微波诱导的心脏组织损伤。
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