Jamil Ahmad Zeeshan, Ahmed Arslan, Mirza Khurram Azam
Department of Ophthalmology, Rashid Latif Medical College, Ferozpur Road, Lahore.
Department of Ophthalmology, LRBT Eye Hospital, Lahore.
J Coll Physicians Surg Pak. 2014 Apr;24(4):245-8.
To evaluate the effect of intracameral dexamethasone on corneal endothelium.
Quasi experimental study.
Layton Rehmatulla Benevolent Trust Eye Hospital, Lahore, from May 2011 to January 2012.
Study subjects were adults of either gender with senile cataract who underwent phacoemulsification. They were divided in two groups, each had 110 patients. Group-A received subconjunctival injection of dexamethasone (2 mg/0.5 ml) at the end of surgery while group-B received intracameral injection of dexamethasone (0.4 mg/0.1 ml) at the end of surgery. Endothelial cell count was performed by specular microscopy pre-operatively and postoperatively at first week, first month and three months. Outcome measures included changes in endothelial cell count. Results were compared using t-test for means.
There were 55 (50%) males and 55 (50%) females in group-A and 44 (40%) males and 66 (60%) females in group-B. In group-A, there were 66 (60%) right and 44 (40%) left eyes while group-B had 62 (56.36%) right and 48 (43.63%) left eyes. Mean age in group-A was 55.17 ± 5.93 years and 54.87 ± 5.55 years in group-B. Mean phacoemulsification time in group-A was 1.92 ± 0.63 minutes and 1.82 ± 0.54 minutes in group-B. After 3 months, in group-A, there was 7.55 ± 1.19% endothelial cell loss while in group-B, there was 7.63 ± 1.10% endothelial cell loss. The difference between the two groups was not statistically significant (p=0.614).
Use of intracameral dexamethasone at the end of cataract surgery is safe for corneal endothelium.
评估前房内注射地塞米松对角膜内皮的影响。
准实验研究。
拉合尔的莱顿·雷赫马图拉慈善信托眼科医院，2011年5月至2012年1月。
研究对象为接受白内障超声乳化手术的老年白内障成年患者，不限性别。他们被分为两组，每组110例患者。A组在手术结束时接受结膜下注射地塞米松（2毫克/0.5毫升），而B组在手术结束时接受前房内注射地塞米松（0.4毫克/0.1毫升）。术前及术后第1周、第1个月和第3个月通过镜面显微镜进行内皮细胞计数。观察指标包括内皮细胞计数的变化。采用t检验比较两组均值。
A组有55例（50%）男性和55例（50%）女性，B组有44例（40%）男性和66例（60%）女性。A组右眼66例（60%），左眼44例（40%）；B组右眼62例（56.36%），左眼48例（43.63%）。A组平均年龄为55.17±5.93岁，B组为54.87±5.55岁。A组平均超声乳化时间为1.92±0.63分钟，B组为1.82±0.54分钟。3个月后，A组内皮细胞损失率为7.55±1.19%，B组为7.63±1.10%。两组之间的差异无统计学意义（p=0.614）。
白内障手术结束时使用前房内地塞米松对角膜内皮是安全的。
