Bayat Alper Halil, Karataş Gamze, Kurt Muhammet Mustafa, Elçioğlu Mustafa Nuri
Department of Ophthalmology, Esenler Hospital, Medipol University, APT: 5 Bahceler, AVE Esenler, Istanbul 34250, Turkey.
Department of Ophthalmology, Okmeydanı Research &Traning Hospital, University of Health Sciences, İstanbul, Turkey.
Ther Adv Ophthalmol. 2020 Aug 6;12:2515841420947544. doi: 10.1177/2515841420947544. eCollection 2020 Jan-Dec.
To evaluate the corneal effects of the intravitreal dexamethasone implantation using corneal topography and specular microscopy.
27 eyes of the 27 patients who received a single intravitreal dexamethasone implantation dose for diabetic macular edema were enrolled in this study. Sirius topography and EM-3000 specular microscopic examinations were performed at the initial examination (baseline), and then on the first day, during the first week, and 1 month after IDI. Changes in corneal parameters were investigated.
The mean age was 58.66 ± 6.59 years. 15 patients were men, and 12 were women. The mean disease duration was 12.2 ± 2.4 months, and mean glycosylated hemoglobin (HbA1c) was 7.2 ± 1.1. After dexamethasone injection, the mean central corneal thickness, endothelial cell density, and coefficient variation of cell area presented a statistically significant decrease ( < 0.05). Anterior segment parameters, such as anterior chamber depth, iridocorneal angle, sim K1 and K2 keratometry, pupillary diameter, horizontal visible iris diameter, and corneal astigmatism did not change ( > 0.05).
Intravitreal dexamethasone implantation affects corneal endothelial cell structure but does not appear to affect corneal topography parameters.
使用角膜地形图和镜面显微镜评估玻璃体内注射地塞米松植入物对角膜的影响。
本研究纳入了27例接受单次玻璃体内注射地塞米松植入物治疗糖尿病性黄斑水肿的患者的27只眼。在初次检查（基线）时进行Sirius角膜地形图和EM - 3000镜面显微镜检查，然后在玻璃体内注射地塞米松植入物后的第1天、第1周和1个月进行检查。研究角膜参数的变化。
平均年龄为58.66±6.59岁。男性15例，女性12例。平均病程为12.2±2.4个月，平均糖化血红蛋白（HbA1c）为7.2±1.1。注射地塞米松后，中央角膜厚度、内皮细胞密度和细胞面积变异系数均呈现出统计学显著下降（P<0.05）。前房深度、虹膜角膜角、sim K1和K2角膜曲率、瞳孔直径、水平可见虹膜直径和角膜散光等眼前节参数未发生变化（P>0.05）。
玻璃体内注射地塞米松植入物会影响角膜内皮细胞结构，但似乎不会影响角膜地形图参数。
