Sasagawa I, Satomi S, Katayama T
Dept. of Urology, Saiseikai Fukushima General Haspital.
Gan No Rinsho. 1989 May;35(6):767-71.
A 60-year-old man was admitted to our hospital because of lumbago due to a metastatic bone tumor that originated from the prostate. Previously, he had been treated with 500 mg/kg of diethylstilbestrol diphosphate and 75 mg/day of chlormadinone acetate. At our hospital, he was given 470.1 mg/day of estramustine sodium phosphate and a bilateral orchiectomy was performed. However, he felt increased lumbago. Thus, a dose of 1200 mg/day of medroxyprogesterone acetate was started. Although the histology of his prostate and bone scintigram did not change, the patient no longer felt lumbago from about 2 weeks after the start of this treatment. Six months later, he remains free of lumbago. In this report, we describe the effect of high-dose medroxyprogesterone acetate on the clinical course, and the plasma and urine levels of the hormones.
一名60岁男性因前列腺来源的转移性骨肿瘤导致腰痛入院。此前，他接受过500mg/kg的磷酸己烯雌酚和75mg/天的醋酸氯地孕酮治疗。在我院，给予他470.1mg/天的磷酸雌莫司汀，并进行了双侧睾丸切除术。然而，他感到腰痛加重。因此，开始给予1200mg/天的醋酸甲羟孕酮。尽管他的前列腺组织学和骨闪烁显像没有变化，但自该治疗开始约2周后，患者不再感到腰痛。6个月后，他仍然没有腰痛症状。在本报告中，我们描述了高剂量醋酸甲羟孕酮对临床病程以及激素血浆和尿液水平的影响。
