Beaufort F, Gölles M
Onkologie. 1984 Jun;7(3):137-40. doi: 10.1159/000215425.
48 patients with metastatic breast cancer and extensive bone involvement were treated with salm-calcitonin and polychemo-therapy or hormonal treatment. They were compared with a control group of 73 patients without calcitonin therapy. One third of the patients from the calcitonin group referred pain relief which was obviously independent from the therapy effects of the polychemo or hormonal treatment. Since only subjective criteria for sceletal pains were used and no therapy arm with calcitonin alone was studied, the results of our study have to be critically analyzed together with other reports about calcitonin and bone metastases in the literature.
48例转移性乳腺癌伴广泛骨转移患者接受了鲑降钙素联合多药化疗或激素治疗。将他们与73例未接受降钙素治疗的对照组患者进行比较。降钙素组中有三分之一的患者表示疼痛缓解，这显然与多药化疗或激素治疗的效果无关。由于仅采用了骨骼疼痛的主观标准，且未研究单独使用降钙素的治疗组，因此我们的研究结果必须与文献中其他有关降钙素和骨转移的报告一起进行批判性分析。
