Department of Urology, College of Medicine, Soonchunhyang University, Seoul Hospital, Seoul, South Korea.
Department of Urology, College of Medicine, Soonchunhyang University, Seoul Hospital, Seoul, South Korea.
Urology. 2014 Jul;84(1):27-31. doi: 10.1016/j.urology.2014.01.026. Epub 2014 Apr 4.
To determine the relationship between body mass index (BMI), visceral adipose tissue (VAT), and stone components.
A cross-sectional study has been done for urinary stone cohort between 2010 and 2012. Data on patient's age, gender, BMI, urinary pH, stone components, and VAT using computed tomography-based delineation were collected. Obesity was defined as BMI≥25 kg/m2 or as VAT≥100 cm2. To compare the differences between the types of stones, multinomial logistic regression analyses were conducted.
Of 203 cases, 49.3% patients were obese based on BMI, and 65.5% were obese using VAT criteria. Multinomial logistic regression analysis revealed that obesity defined by VAT was found to be associated with uric acid stones compared with calcium phosphate stones (odds ratio [OR] 6.544, 95% confidence interval [CI], P=.030) and mixed calcium oxalate phosphate stones (OR 5.582, 95% CI, P=.038). Similar results were observed in calcium oxalate stones over calcium phosphate stones (OR 2.984, 95% CI, P=.032) and calcium oxalate phosphate stones (OR 2.542, 95% CI, P=.041). On the contrary, obesity defined based on BMI has no correlation over all types of urinary stone components.
This result implies that VAT has a more important role in uric acid and calcium oxalate stone formation than total body fat, represented by BMI.
确定体重指数（BMI）、内脏脂肪组织（VAT）与结石成分之间的关系。
本研究为 2010 年至 2012 年间进行的一项尿石症队列的横断面研究。收集了患者年龄、性别、BMI、尿 pH 值、结石成分以及使用基于 CT 的勾画的 VAT 数据。肥胖定义为 BMI≥25kg/m2 或 VAT≥100cm2。采用多项逻辑回归分析比较不同类型结石之间的差异。
在 203 例患者中，49.3%的患者根据 BMI 肥胖，65.5%的患者根据 VAT 标准肥胖。多项逻辑回归分析显示，与磷酸钙结石相比，VAT 定义的肥胖与尿酸结石相关（比值比 [OR] 6.544，95%置信区间 [CI]，P=.030）和混合草酸钙磷酸结石（OR 5.582，95%CI，P=.038）。在草酸钙结石与磷酸钙结石（OR 2.984，95%CI，P=.032）和草酸钙磷酸结石（OR 2.542，95%CI，P=.041）之间也观察到了类似的结果。相反，BMI 定义的肥胖与所有类型的尿石成分均无相关性。
这一结果表明，VAT 在尿酸和草酸钙结石形成中的作用比 BMI 所代表的全身脂肪更为重要。
