Tzeng Thing-Fong, Lu Hung-Jen, Liou Shorong-Shii, Chang Chia Ju, Liu I-Min
Department of Internal Medicine, Pao Chien Hospital, Ping Tung City, Pingtung County, Taiwan, ROC.
Traditional Medicinal Center, Kaohsiung Veterans General Hospital, Kaohsiung City, Taiwan, ROC.
Food Chem Toxicol. 2014 Jul;69:132-9. doi: 10.1016/j.fct.2014.03.036. Epub 2014 Apr 5.
We investigated the effects of zerumbone, a natural cyclic sesquiterpene of Zingiber zerumbet Smith, on high-fat diet (HFD)-induced hyperlipidemic hamsters. After being fed HFD for 2 weeks, Syrian golden hamsters were dosed orally with zerumbone (25, 50, and 100 mg/kg) once daily for 8 weeks. Decreased plasma levels of TC, TG and LDL-C, as well as the concentrations of hepatic lipids, with a simultaneous increase in fecal lipids were found. The ratios of LDL-C/HDL-C and TC/HDL-C were elevated by zerumbone. Zerumbone exhibited the ability to decreased hepatic mRNA levels of fatty acid synthase, malic enzyme, sterol-regulatory element binding protein and 3-hydroxy-3-methyl-glutaryl-CoA reductase reductase. The hepatic mRNA expression of peroxisome proliferator-activated receptor α, together with its target gene carnitine palmitoyl transferase and acyl-CoA oxidase were also upregulated by zerumbone. Zerumbone is effective to improve dyslipidemia by modulating the genes expression involving in the lipolytic and lipogenic pathways of lipids metabolism.
我们研究了莪术二酮（一种来源于莪术的天然环状倍半萜）对高脂饮食（HFD）诱导的高脂血症仓鼠的影响。叙利亚金黄地鼠在高脂饮食喂养2周后，每天口服一次莪术二酮（25、50和100 mg/kg），持续8周。结果发现，血浆中总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-C）水平降低，肝脏脂质浓度降低，同时粪便脂质增加。莪术二酮提高了低密度脂蛋白胆固醇与高密度脂蛋白胆固醇（HDL-C）的比值以及总胆固醇与高密度脂蛋白胆固醇的比值。莪术二酮能够降低脂肪酸合酶、苹果酸酶、固醇调节元件结合蛋白和3-羟基-3-甲基戊二酰辅酶A还原酶的肝脏mRNA水平。莪术二酮还上调了过氧化物酶体增殖物激活受体α及其靶基因肉碱棕榈酰转移酶和酰基辅酶A氧化酶的肝脏mRNA表达。莪术二酮通过调节参与脂质代谢的脂解和脂肪生成途径的基因表达，有效改善血脂异常。
