Department of Mechanical Engineering, Faculty of Engineering, University of Malaya, Kuala Lumpur 50603, Malaysia.
Centre of Advanced Materials (CAM), Faculty of Engineering, University of Malaya, Kuala Lumpur 50603, Malaysia.
Molecules. 2017 Sep 30;22(10):1645. doi: 10.3390/molecules22101645.
Zerumbone (ZER) is a phytochemical isolated from the subtropical Zingiberaceae family and as a natural compound it has different biomedical properties such as antioxidant, anti-inflammatory anti-proliferative activity. ZER also has effects on angiogenesis and acts as an antitumor drug in the treatment of cancer, showing selective toxicity toward various cancer cell lines. Several techniques also have been established for extraction of ZER from the rhizomes of ginger. This review paper is an overview of recent research about different extraction methods and their efficiencies, in vivo and vitro investigations of ZER and also its prominent chemopreventive properties and treatment mechanisms. Most of the studies mentioned in this review paper may be useful use as a knowledge summary to explain ZER extraction and anticancer activities, which will show a way for the development of strategies in the treatment of malignancies using ZER.
姜烯酮（ZER）是一种从亚热带姜科植物中分离出来的植物化学物质，作为一种天然化合物，它具有不同的生物医学特性，如抗氧化、抗炎、抗增殖活性。ZER 还对血管生成有影响，并在癌症治疗中作为一种抗肿瘤药物，对各种癌细胞系表现出选择性毒性。已经建立了几种从姜根茎中提取 ZER 的技术。这篇综述论文概述了最近关于不同提取方法及其效率的研究，ZER 的体内和体外研究，以及其突出的化学预防特性和治疗机制。本文中提到的大多数研究可能有助于作为知识总结来解释 ZER 的提取和抗癌活性，这将为使用 ZER 开发治疗恶性肿瘤的策略提供一种方法。
