Institut de Pharmacologie Moléculaire et Cellulaire, CNRS UMR 7275, Université de Nice-Sophia Antipolis, 660 route des Lucioles, Valbonne 06560, France.
Cells. 2013 Mar 4;2(1):124-35. doi: 10.3390/cells2010124.
The neuropeptide, neurotensin, exerts numerous biological functions, including an efficient anti-apoptotic role, both in the central nervous system and in the periphery. This review summarizes studies that clearly evidenced the protective effect of neurotensin through its three known receptors. The pivotal involvement of the neurotensin receptor-3, also called sortilin, in the molecular mechanisms of the anti-apoptotic action of neurotensin has been analyzed in neuronal cell death, in cancer cell growth and in pancreatic beta cell protection. The relationships between the anti-apoptotic role of neurotensin and important physiological and pathological contexts are discussed in this review.
神经肽神经降压素具有多种生物学功能，包括在中枢神经系统和外周组织中发挥有效的抗细胞凋亡作用。这篇综述总结了多项研究，这些研究明确证实了神经降压素通过其三种已知受体发挥保护作用。神经降压素受体-3（也称为分选蛋白）在神经降压素抗细胞凋亡作用的分子机制中的关键作用已在神经元细胞死亡、癌细胞生长和胰岛β细胞保护中得到分析。本文综述了神经降压素的抗细胞凋亡作用与重要的生理和病理环境之间的关系。
