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Y 编码 TSPY 的表达与前列腺癌的进展有关。

Expression of the Y-Encoded TSPY is Associated with Progression of Prostate Cancer.

机构信息

Division of Cell and Developmental Genetics, Department of Medicine, VA Medical Center, University of California, San Francisco, CA 94121, USA.

Department of Urology, Hirosaki University School of Medicine, Hirosaki 036-8562, Japan.

出版信息

Genes (Basel). 2010 Sep 14;1(2):283-93. doi: 10.3390/genes1020283.

DOI:10.3390/genes1020283
PMID:24710046
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3954091/
Abstract

TSPY is a Y-encoded gene that is expressed in normal testicular germ cells and various cancer types including germ cell tumor, melanoma, hepatocellular carcinoma, and prostate cancer. Currently, the correlation between TSPY expression and oncogenic development has not been established, particularly in somatic cancers. To establish such correlation, we analyzed the expression of TSPY, in reference to its interactive oncoprotein, EEF1A, tumor biomarker, AMACR, and normal basal cell biomarker, p63, in 41 cases of clinical prostate cancers (CPCa), 17 cases of latent prostate cancers (LPCa), and 19 cases of non-cancerous prostate (control) by immunohistochemistry. Our results show that TSPY was detected more frequently (78%) in the clinical prostate cancer specimens than those of latent prostate cancer (47%) and control (50%). In the latent cancer group, the levels of TSPY expression could be correlated with increasing Gleason grades. TSPY expression was detected in seven out of nine high-grade latent cancer samples (Gleason 7 and more). The expression of the TSPY binding partner EEF1A was detectable in all prostate specimens, but the levels were higher in cancer cells in clinical and latent prostate cancer specimens than normal prostatic cells. These observations suggest that expressions of TSPY and its binding partner EEF1A are associated with the development and progression of prostate cancer.

摘要

TSPY 是一种 Y 编码基因，在正常睾丸生殖细胞和各种癌症类型中表达，包括生殖细胞瘤、黑色素瘤、肝细胞癌和前列腺癌。目前，TSPY 表达与致癌发展之间的相关性尚未确定，特别是在体细胞癌中。为了建立这种相关性，我们通过免疫组织化学分析了 41 例临床前列腺癌（CPCa）、17 例潜伏前列腺癌（LPCa）和 19 例非癌前列腺（对照）组织中 TSPY 的表达，参考其相互作用的致癌蛋白 EEF1A、肿瘤生物标志物 AMACR 和正常基底细胞生物标志物 p63。我们的结果表明，TSPY 在临床前列腺癌标本中的检出率（78%）高于潜伏前列腺癌（47%）和对照组（50%）。在潜伏癌组中，TSPY 表达水平与 Gleason 分级的增加有关。在 9 例高分级潜伏癌样本中（Gleason 7 及以上）有 7 例检测到 TSPY 表达。TSPY 结合伴侣 EEF1A 的表达可在所有前列腺标本中检测到，但在临床和潜伏前列腺癌标本中的癌细胞中的表达水平高于正常前列腺细胞。这些观察结果表明，TSPY 及其结合伴侣 EEF1A 的表达与前列腺癌的发生和发展有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce3a/3954091/84b64789d74b/genes-01-00283-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce3a/3954091/34211e7ef463/genes-01-00283-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce3a/3954091/1213928bdb5f/genes-01-00283-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce3a/3954091/84b64789d74b/genes-01-00283-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce3a/3954091/34211e7ef463/genes-01-00283-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce3a/3954091/1213928bdb5f/genes-01-00283-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ce3a/3954091/84b64789d74b/genes-01-00283-g003.jpg

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The interleukin-8 pathway in cancer.癌症中的白细胞介素-8信号通路。
Clin Cancer Res. 2008 Nov 1;14(21):6735-41. doi: 10.1158/1078-0432.CCR-07-4843.
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Prostate tumor progression is mediated by a paracrine TGF-beta/Wnt3a signaling axis.前列腺肿瘤进展由旁分泌转化生长因子-β/翼状胬肉相关蛋白3a信号轴介导。
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The Y-linked proto-oncogene TSPY contributes to poor prognosis of the male hepatocellular carcinoma patients by promoting the pro-oncogenic and suppressing the anti-oncogenic gene expression.Y 连锁原癌基因 TSPY 通过促进促癌基因表达和抑制抑癌基因表达，导致男性肝细胞癌患者预后不良。
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Testis-specific protein, Y-linked 1 activates PI3K/AKT and RAS signaling pathways through suppressing IGFBP3 expression during tumor progression.睾丸特异性蛋白 Y 连锁 1 在肿瘤进展过程中通过抑制 IGFBP3 的表达来激活 PI3K/AKT 和 RAS 信号通路。
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TSPY1 suppresses USP7-mediated p53 function and promotes spermatogonial proliferation.TSPY1 抑制 USP7 介导的 p53 功能并促进精原细胞增殖。
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The Y-located proto-oncogene TSPY exacerbates and its X-homologue TSPX inhibits transactivation functions of androgen receptor and its constitutively active variants.位于Y染色体上的原癌基因TSPY会加剧这种情况，而其位于X染色体上的同源基因TSPX则会抑制雄激素受体及其组成型活性变体的反式激活功能。
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Sexual dimorphism in cancer.癌症中的性别二态性。
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The human Y-encoded testis-specific protein interacts functionally with eukaryotic translation elongation factor eEF1A, a putative oncoprotein.人类Y编码的睾丸特异性蛋白与真核生物翻译延伸因子eEF1A（一种假定的癌蛋白）在功能上相互作用。
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