• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

FXR: the key to benefits in bariatric surgery?

作者信息

Kuipers Folkert, Groen Albert K

机构信息

Departments of Pediatrics and Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

出版信息

Nat Med. 2014 Apr;20(4):337-8. doi: 10.1038/nm.3525.

DOI:10.1038/nm.3525
PMID:24710375
Abstract
摘要

相似文献

1
FXR: the key to benefits in bariatric surgery?法尼酯X受体：减肥手术获益的关键？
Nat Med. 2014 Apr;20(4):337-8. doi: 10.1038/nm.3525.
2
Changes in Bile Acid Metabolism, Transport, and Signaling as Central Drivers for Metabolic Improvements After Bariatric Surgery.胆汁酸代谢、转运和信号转导的变化作为减重手术后代谢改善的核心驱动因素。
Curr Obes Rep. 2019 Jun;8(2):175-184. doi: 10.1007/s13679-019-00334-4.
3
Bile acids and bariatric surgery.胆汁酸与减肥手术
Mol Aspects Med. 2017 Aug;56:75-89. doi: 10.1016/j.mam.2017.04.001. Epub 2017 Apr 17.
4
Bariatric surgery in patients with type 2 diabetes: benefits, risks, indications and perspectives.肥胖症手术治疗 2 型糖尿病：获益、风险、适应证和展望。
Diabetes Metab. 2009 Dec;35(6 Pt 2):537-43. doi: 10.1016/S1262-3636(09)73463-9.
5
[Surgery for morbid obesity and diabetes mellitus--from bariatric surgery to metabolic surgery].[病态肥胖症与糖尿病的外科治疗——从减重手术到代谢手术]
Fukuoka Igaku Zasshi. 2013 Nov;104(11):397-404.
6
Effects of various gastrointestinal procedures on β-cell function in obesity and type 2 diabetes.各种胃肠道手术对肥胖症和2型糖尿病患者β细胞功能的影响。
Surg Obes Relat Dis. 2016 Jul;12(6):1213-9. doi: 10.1016/j.soard.2016.02.035. Epub 2016 Mar 2.
7
The role of bile acids in reducing the metabolic complications of obesity after bariatric surgery: a systematic review.减肥手术后胆汁酸在减轻肥胖代谢并发症中的作用：一项系统评价
Int J Obes (Lond). 2015 Nov;39(11):1565-74. doi: 10.1038/ijo.2015.115. Epub 2015 Jun 17.
8
Role of Bile Acids and GLP-1 in Mediating the Metabolic Improvements of Bariatric Surgery.胆汁酸和 GLP-1 在介导减重手术代谢改善中的作用。
Gastroenterology. 2019 Mar;156(4):1041-1051.e4. doi: 10.1053/j.gastro.2018.11.017. Epub 2018 Nov 13.
9
Improved glucose metabolism following bariatric surgery is associated with increased circulating bile acid concentrations and remodeling of the gut microbiome.减肥手术后葡萄糖代谢的改善与循环胆汁酸浓度的增加和肠道微生物群的重塑有关。
World J Gastroenterol. 2016 Oct 21;22(39):8698-8719. doi: 10.3748/wjg.v22.i39.8698.
10
In bariatric surgery, less might be more: let's let the patient decide.在减肥手术中，少或许就是多：让我们让患者来决定。
Am J Med. 2009 Jun;122(6):e9; author reply e11. doi: 10.1016/j.amjmed.2008.10.033.

引用本文的文献

1
Neurohormonal Changes in the Gut-Brain Axis and Underlying Neuroendocrine Mechanisms following Bariatric Surgery.减肥手术后肠道-脑轴的神经激素变化及潜在神经内分泌机制
Int J Mol Sci. 2022 Mar 19;23(6):3339. doi: 10.3390/ijms23063339.
2
Nutrients handling after bariatric surgery, the role of gastrointestinal adaptation.减重手术后的营养素处理，胃肠道适应的作用。
Eat Weight Disord. 2022 Mar;27(2):449-461. doi: 10.1007/s40519-021-01194-5. Epub 2021 Apr 24.
3
Changes in fasting bile acid profiles after Roux-en-Y gastric bypass and sleeve gastrectomy.

本文引用的文献

1
FXR is a molecular target for the effects of vertical sleeve gastrectomy.FXR 是垂直袖状胃切除术作用的分子靶点。
Nature. 2014 May 8;509(7499):183-8. doi: 10.1038/nature13135. Epub 2014 Mar 26.
2
Long-term drug treatment for obesity: a systematic and clinical review.长期药物治疗肥胖：系统评价和临床综述。
JAMA. 2014 Jan 1;311(1):74-86. doi: 10.1001/jama.2013.281361.
3
Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity.微生物组重塑导致肠道法尼醇 X 受体信号抑制和肥胖减少。
Roux-en-Y胃旁路术和袖状胃切除术后空腹胆汁酸谱的变化。
Medicine (Baltimore). 2021 Jan 22;100(3):e23939. doi: 10.1097/MD.0000000000023939.
4
Mechanisms of Interactions between Bile Acids and Plant Compounds-A Review.胆汁酸与植物化合物相互作用的机制研究进展。
Int J Mol Sci. 2020 Sep 5;21(18):6495. doi: 10.3390/ijms21186495.
5
"Dysfunctions" induced by Roux-en-Y gastric bypass surgery are concomitant with metabolic improvement independent of weight loss.Roux-en-Y胃旁路手术引起的“功能障碍”与代谢改善同时出现，且与体重减轻无关。
Cell Discov. 2020 Jan 28;6:4. doi: 10.1038/s41421-019-0138-2. eCollection 2020.
6
Recent advancements in bariatric/metabolic surgery.减肥/代谢手术的最新进展。
Ann Gastroenterol Surg. 2017 Sep 10;1(3):171-179. doi: 10.1002/ags3.12030. eCollection 2017 Sep.
7
Intestinal and Gastric Origins for Diabetes Resolution After Bariatric Surgery.减重手术后糖尿病缓解的肠和胃起源。
Curr Obes Rep. 2018 Jun;7(2):139-146. doi: 10.1007/s13679-018-0302-2.
8
Proceedings of the 2017 ASPEN Research Workshop-Gastric Bypass: Role of the Gut.2017 年 ASPEN 研究研讨会会议记录-胃旁路术：肠道的作用。
JPEN J Parenter Enteral Nutr. 2018 Feb;42(2):279-295. doi: 10.1002/jpen.1121.
9
Impact of Fibroblast Growth Factors 19 and 21 in Bariatric Metabolism.成纤维细胞生长因子19和21在减肥代谢中的作用
Dig Dis. 2017;35(3):191-196. doi: 10.1159/000450910. Epub 2017 Mar 1.
10
Improved glucose metabolism following bariatric surgery is associated with increased circulating bile acid concentrations and remodeling of the gut microbiome.减肥手术后葡萄糖代谢的改善与循环胆汁酸浓度的增加和肠道微生物群的重塑有关。
World J Gastroenterol. 2016 Oct 21;22(39):8698-8719. doi: 10.3748/wjg.v22.i39.8698.
Nat Commun. 2013;4:2384. doi: 10.1038/ncomms3384.
4
Weight loss induced by Roux-en-Y gastric bypass but not laparoscopic adjustable gastric banding increases circulating bile acids.Roux-en-Y 胃旁路手术引起的体重减轻会增加循环胆汁酸，而腹腔镜可调节胃束带术则不会。
J Clin Endocrinol Metab. 2013 Apr;98(4):E708-12. doi: 10.1210/jc.2012-3736. Epub 2013 Mar 1.
5
Insight into the prebiotic concept: lessons from an exploratory, double blind intervention study with inulin-type fructans in obese women.深入了解益生元概念：菊粉型果聚糖干预肥胖女性的探索性、双盲干预研究的启示。
Gut. 2013 Aug;62(8):1112-21. doi: 10.1136/gutjnl-2012-303304. Epub 2012 Nov 7.
6
Bariatric surgery versus intensive medical therapy in obese patients with diabetes.肥胖伴糖尿病患者的减肥手术与强化内科治疗的比较。
N Engl J Med. 2012 Apr 26;366(17):1567-76. doi: 10.1056/NEJMoa1200225. Epub 2012 Mar 26.
7
Loss of FXR protects against diet-induced obesity and accelerates liver carcinogenesis in ob/ob mice.FXR缺失可预防饮食诱导的肥胖，并加速ob/ob小鼠的肝癌发生。
Mol Endocrinol. 2012 Feb;26(2):272-80. doi: 10.1210/me.2011-1157. Epub 2012 Jan 19.
8
Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity.法尼醇 X 受体缺失可改善肥胖症小鼠模型的葡萄糖稳态。
Diabetes. 2011 Jul;60(7):1861-71. doi: 10.2337/db11-0030. Epub 2011 May 18.
9
Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism.接受过胃旁路手术的人群血清胆汁酸水平较高：对改善葡萄糖和脂质代谢的潜在作用。
Obesity (Silver Spring). 2009 Sep;17(9):1671-7. doi: 10.1038/oby.2009.102. Epub 2009 Apr 9.
10
Role of bile acids and bile acid receptors in metabolic regulation.胆汁酸及胆汁酸受体在代谢调节中的作用
Physiol Rev. 2009 Jan;89(1):147-91. doi: 10.1152/physrev.00010.2008.