Lown R N, Philippe J, Navarro W, van Walraven S M, Philips-Johnson L, Fechter M, Pawson R, Bengtsson M, Beksac M, Field S, Yang H, Shaw B E
1] Anthony Nolan Research Institute, UCL Cancer Institute, London, UK [2] Royal Marsden NHS Foundation Trust, London, UK.
OneMatch Stem Cell and Marrow Network, Ottawa, Ontario, Canada.
Bone Marrow Transplant. 2014 Jul;49(7):880-6. doi: 10.1038/bmt.2014.67. Epub 2014 Apr 7.
The World Marrow Donor Association (WMDA) fosters collaboration between international registries to facilitate the exchange of hematopoietic stem cell products for unrelated stem cell donor transplantation. As indications for hematopoietic SCT grow, the movement of products across the world will increase. Although competent authorities may regulate products within their country, there is a need to protect the best interests of donors and recipients by identifying universal donor medical suitability criteria. Within this report the WMDA provides a background to unrelated adult donor and recipient safety, recommends a common framework for assessing the health of unrelated adult donors at each stage of the donation pathway and presents a novel mechanism for sharing international consensus criteria for individual medical and lifestyle conditions. Wherever possible, these criteria are evidence-based. By establishing a donor medical suitability working group, the WMDA has developed a process through which donor centers and registries may request a consensus opinion on conditions not already listed, as well as challenge existing criteria. Guidance from the WMDA is intended to complement, not supersede, guidance from national competent authorities and international regulatory bodies.
世界骨髓捐献者协会（WMDA）促进国际骨髓库之间的合作，以推动非血缘干细胞供者移植中造血干细胞产品的交换。随着造血干细胞移植适应证的增加，产品在全球范围内的流动将会增多。尽管主管当局可能会对本国境内的产品进行监管，但有必要通过确定通用的供者医学适用性标准来保护供者和受者的最大利益。在本报告中，WMDA介绍了非血缘成年供者和受者安全的背景情况，推荐了在捐献流程各阶段评估非血缘成年供者健康状况的通用框架，并提出了一种分享针对个体医学和生活方式状况的国际共识标准的新机制。只要有可能，这些标准都以证据为基础。通过设立一个供者医学适用性工作组，WMDA制定了一个流程，供者中心和骨髓库可据此就未列出的状况请求达成共识意见，并对现有标准提出质疑。WMDA的指导旨在补充而非取代国家主管当局和国际监管机构的指导。
