Kamar Francois G, Kairouz Victor F, Nasser Selim M, Faddoul Sami G, Saikali Ibrahim C
Division of Hematology and Oncology, Clemenceau Medical Center , Beirut, Lebanon, USA ; Lebanese American University, School of Medicine , Byblos, Lebanon, USA.
Buffalo University , New York, NY, USA.
Rare Tumors. 2014 Mar 18;6(1):4687. doi: 10.4081/rt.2014.4687. eCollection 2014 Jan 23.
Choroid plexus papillomas (CPPs) are usually not malignant and occur in less than 1% of brain tumors in patients of all ages. They represent 3% of childhood intracranial neoplasms with a predilection in younger ages. Papillomas have an indolent course and carry a good long-term outcome if gross total surgical resection is achieved. However malignant evolution may occur, with a 10-30% incidence. Chemotherapy has been used with varied degrees of success. Most series are very small, some are only limited to case reports and cannot lead to guidelines or therapeutic recommendations. We are reporting the first case of recurrent CPP treated with 5 mg/kg of bevacizumab administered once every two weeks. Complete patient evaluations with follow-up contrast-enhanced magnetic resonance imaging (MRI) scans were obtained after the initial two treatments and every 8 weeks thereafter. Only after two treatments, the MRI scans showed radiological stabilization of the tumor, and the patient achieved an excellent clinical response with significant resolution of all skin lesions.
脉络丛乳头状瘤（CPPs）通常为良性，在各年龄段患者的脑肿瘤中发生率不到1%。在儿童颅内肿瘤中占3%，发病年龄较轻。乳头状瘤病程进展缓慢，如果能实现肿瘤全切，长期预后良好。然而，可能会发生恶性演变，发生率为10% - 30%。化疗取得了不同程度的成功。大多数研究系列样本量非常小，有些仅局限于病例报告，无法形成指南或治疗建议。我们报告首例复发性CPPs患者，每两周接受一次5mg/kg贝伐单抗治疗。在最初两次治疗后及此后每8周进行一次增强磁共振成像（MRI）扫描，对患者进行全面评估。仅经过两次治疗，MRI扫描显示肿瘤在影像学上稳定，患者临床反应良好，所有皮肤病变明显消退。
