Wang Lv, Conlon Michael Allan, Christophersen Claus Thagaard, Sorich Michael Joseph, Angley Manya Therese
Sansom Institute for Health Research, University of South Australia, GPO Box 2471, Adelaide, SA 5001, Australia.
Biomark Med. 2014;8(3):331-44. doi: 10.2217/bmm.14.12.
Autism spectrum disorder (ASD) is a neurodevelopmental disorder. Many affected individuals also display symptoms of gastrointestinal (GI) disturbance, suggesting GI factors may play an important role in the pathogenesis of ASD and/or related complications. The current review will focus on evidence supporting a role for the GI microbiota and their fermentation products in the etiology and/or symptoms of ASD, and their potential use as biomarkers. GI-related biomarkers could potentially enable early identification of ASD at risk of GI disturbance, and thereby guide targeted interventions, potentially improving the health and quality of life of affected individuals.
自闭症谱系障碍（ASD）是一种神经发育障碍。许多受影响的个体还表现出胃肠道（GI）紊乱的症状，这表明胃肠道因素可能在ASD的发病机制和/或相关并发症中起重要作用。本综述将聚焦于支持胃肠道微生物群及其发酵产物在ASD的病因和/或症状中发挥作用的证据，以及它们作为生物标志物的潜在用途。与胃肠道相关的生物标志物可能有助于早期识别有胃肠道紊乱风险的ASD，从而指导针对性干预，有可能改善受影响个体的健康和生活质量。
