Basati Gholam, Razavi Amirnader Emami, Abdi Soheila, Sarrafzedegan Nizal
Department of Clinical Biochemistry, Faculty of Allied Medical Sciences, Ilam University of Medical Sciences, Ilam, Iran.
Biomark Med. 2014;8(3):405-12. doi: 10.2217/bmm.13.131.
Leptin and total homocysteine (tHcy) may participate in the pathogenesis of coronary artery disease (CAD) through nitric oxide (NO) depletion. We sought to investigate whether leptin, tHcy and NO are suitable predictors of CAD.
PATIENTS & METHODS: This study contained 50 control subjects and 50 stable and 50 unstable angina patients. Plasma leptin, tHcy and NO levels were determined using enzyme immunoassay, HPLC fluorescence and spectrophotometric methods, respectively. Other conventional risk factors were also determined.
Leptin and tHcy levels were highest in unstable angina patients, followed by stable angina patients and then controls (p < 0.001). Controls had significantly higher NO than patients (p <0.001). Leptin and tHcy had a positive and NO a negative association with the presence of CAD.
Some athrogenic effects of leptin may be mediated by affecting tHcy and NO levels. Plasma leptin, tHcy and NO levels showed significant contribution to CAD prediction and discrimination.
瘦素和总同型半胱氨酸（tHcy）可能通过一氧化氮（NO）消耗参与冠状动脉疾病（CAD）的发病机制。我们试图研究瘦素、tHcy和NO是否为CAD的合适预测指标。
本研究纳入50名对照者、50名稳定型心绞痛患者和50名不稳定型心绞痛患者。分别采用酶免疫测定法、高效液相色谱荧光法和分光光度法测定血浆瘦素、tHcy和NO水平。还测定了其他传统危险因素。
不稳定型心绞痛患者的瘦素和tHcy水平最高，其次是稳定型心绞痛患者，然后是对照者（p<0.001）。对照者的NO水平显著高于患者（p<0.001）。瘦素和tHcy与CAD的存在呈正相关，而NO与CAD呈负相关。
瘦素的一些致动脉粥样硬化作用可能通过影响tHcy和NO水平来介导。血浆瘦素、tHcy和NO水平对CAD的预测和鉴别有显著作用。
