Department of Basic Medical Sciences, Taizhou University, Taizhou, China.
Department of Neurology, Taizhou Second People's Hospital, Taizhou, China.
Ann Clin Transl Neurol. 2020 Nov;7(11):2332-2338. doi: 10.1002/acn3.51227. Epub 2020 Oct 21.
Homocysteine is an essential intermediate product of biochemical reactions that is present in various tissues of the human body. Homocysteine may be associated with the development and progression of Parkinson's disease. Plasma homocysteine levels in patients with Parkinson's disease are elevated compared to those of healthy individuals. High homocysteine drives PD development and progression while aggregating the clinical symptoms of PD patients. The relationship between PD and homocysteine involves multiple pathways, including nerve cell apoptosis, oxidative stress, and DNA damage. This is crucial for explaining how high homocysteine drives the PD procession. Elevated homocysteine level during PD development and progression offers a new strategy for the diagnosis and treatment of this disease.
同型半胱氨酸是人体各种组织中存在的生化反应的必需中间产物。同型半胱氨酸可能与帕金森病的发生和发展有关。与健康个体相比，帕金森病患者的血浆同型半胱氨酸水平升高。高同型半胱氨酸驱动 PD 的发展和进展，同时聚集 PD 患者的临床症状。PD 与同型半胱氨酸之间的关系涉及多个途径，包括神经细胞凋亡、氧化应激和 DNA 损伤。这对于解释高同型半胱氨酸如何驱动 PD 进程至关重要。PD 发展和进展过程中同型半胱氨酸水平升高为该疾病的诊断和治疗提供了新策略。
