同型半胱氨酸在帕金森病发展和进展中的作用。
Role of homocysteine in the development and progression of Parkinson's disease.
机构信息
Department of Basic Medical Sciences, Taizhou University, Taizhou, China.
Department of Neurology, Taizhou Second People's Hospital, Taizhou, China.
出版信息
Ann Clin Transl Neurol. 2020 Nov;7(11):2332-2338. doi: 10.1002/acn3.51227. Epub 2020 Oct 21.
Abstract
Homocysteine is an essential intermediate product of biochemical reactions that is present in various tissues of the human body. Homocysteine may be associated with the development and progression of Parkinson's disease. Plasma homocysteine levels in patients with Parkinson's disease are elevated compared to those of healthy individuals. High homocysteine drives PD development and progression while aggregating the clinical symptoms of PD patients. The relationship between PD and homocysteine involves multiple pathways, including nerve cell apoptosis, oxidative stress, and DNA damage. This is crucial for explaining how high homocysteine drives the PD procession. Elevated homocysteine level during PD development and progression offers a new strategy for the diagnosis and treatment of this disease.
摘要
同型半胱氨酸是人体各种组织中存在的生化反应的必需中间产物。同型半胱氨酸可能与帕金森病的发生和发展有关。与健康个体相比，帕金森病患者的血浆同型半胱氨酸水平升高。高同型半胱氨酸驱动 PD 的发展和进展，同时聚集 PD 患者的临床症状。PD 与同型半胱氨酸之间的关系涉及多个途径，包括神经细胞凋亡、氧化应激和 DNA 损伤。这对于解释高同型半胱氨酸如何驱动 PD 进程至关重要。PD 发展和进展过程中同型半胱氨酸水平升高为该疾病的诊断和治疗提供了新策略。
相似文献
1
Role of homocysteine in the development and progression of Parkinson's disease.同型半胱氨酸在帕金森病发展和进展中的作用。
Ann Clin Transl Neurol. 2020 Nov;7(11):2332-2338. doi: 10.1002/acn3.51227. Epub 2020 Oct 21.
2
Is the deficiency of vitamin B12 related to oxidative stress and neurotoxicity in Parkinson's patients?维生素B12缺乏与帕金森病患者的氧化应激和神经毒性有关吗？
CNS Neurol Disord Drug Targets. 2008 Feb;7(1):20-7. doi: 10.2174/187152708783885101.
3
Homocysteine and Parkinson's disease: a dangerous liaison?同型半胱氨酸与帕金森病：一种危险关联？
J Neurol Sci. 2007 Jun 15;257(1-2):31-7. doi: 10.1016/j.jns.2007.01.028. Epub 2007 Mar 1.
4
The role of one-carbon metabolism and homocysteine in Parkinson's disease onset, pathology and mechanisms.一碳代谢与同型半胱氨酸在帕金森病发病机制、病理中的作用。
Nutr Res Rev. 2019 Dec;32(2):218-230. doi: 10.1017/S0954422419000106. Epub 2019 Jul 15.
5
Hyperhomocysteinemia in L-dopa treated patients with Parkinson's disease: potential implications in cognitive dysfunction and dementia?左旋多巴治疗的帕金森病患者高同型半胱氨酸血症：认知功能障碍和痴呆的潜在影响？
Curr Med Chem. 2010;17(28):3253-61. doi: 10.2174/092986710792232012.
6
Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease.在帕金森病模型中，膳食叶酸缺乏和高同型半胱氨酸水平会危及多巴胺能神经元。
J Neurochem. 2002 Jan;80(1):101-10. doi: 10.1046/j.0022-3042.2001.00676.x.
7
Homocysteine and Parkinson's disease.同型半胱氨酸与帕金森病。
CNS Neurosci Ther. 2024 Feb;30(2):e14420. doi: 10.1111/cns.14420. Epub 2023 Aug 29.
8
Association of Serum Homocysteine Level with Parkinson's Disease.血清同型半胱氨酸水平与帕金森病的关系。
Mymensingh Med J. 2024 Jul;33(3):643-648.
9
Investigating the causality of metabolites involved in one-carbon metabolism with the risk and age at onset of Parkinson's disease: A two-sample mendelian randomization study.采用两样本孟德尔随机化研究探究与帕金森病发病风险和发病年龄相关的一碳代谢物的因果关系。
Neurobiol Aging. 2021 Dec;108:196-199. doi: 10.1016/j.neurobiolaging.2021.06.023. Epub 2021 Jul 4.
10
Association of plasma homocysteine, vitamin B12 and folate levels with cognitive function in Parkinson's disease: A meta-analysis.帕金森病患者血浆同型半胱氨酸、维生素B12和叶酸水平与认知功能的相关性：一项荟萃分析。
Neurosci Lett. 2017 Jan 1;636:190-195. doi: 10.1016/j.neulet.2016.11.007. Epub 2016 Nov 10.
引用本文的文献
1
STAT1 and STAT6 orchestrate Cbs transcription and transsulfur metabolism in microglia and contribute to parkinson's disease-related neuroinflammation.信号转导和转录激活因子1（STAT1）和信号转导和转录激活因子6（STAT6）协调小胶质细胞中胱硫醚β-合成酶（Cbs）的转录和转硫代谢，并促进帕金森病相关神经炎症。
Cell Mol Life Sci. 2025 Jul 30;82(1):294. doi: 10.1007/s00018-025-05768-9.
2
Homocysteinylation of Fibrinogen: A Post-Translational Link to Thrombosis.纤维蛋白原的同型半胱氨酸化：血栓形成的一种翻译后联系。
Int J Mol Sci. 2025 Jun 7;26(12):5471. doi: 10.3390/ijms26125471.
3
Early diagnosis of Parkinson's disease: biomarker study.帕金森病的早期诊断：生物标志物研究。
Front Aging Neurosci. 2025 May 9;17:1495769. doi: 10.3389/fnagi.2025.1495769. eCollection 2025.
4
Parkin characteristics and blood biomarkers of Parkinson's disease in WPBLC study.WPBLC研究中帕金森病的帕金蛋白特征及血液生物标志物
Front Aging Neurosci. 2025 Feb 26;17:1511272. doi: 10.3389/fnagi.2025.1511272. eCollection 2025.
5
Multi-omics characterization of improved cognitive functions in Parkinson's disease patients after the combined metabolic activator treatment: a randomized, double-blinded, placebo-controlled phase II trial.帕金森病患者联合代谢激活剂治疗后认知功能改善的多组学特征：一项随机、双盲、安慰剂对照的II期试验。
Brain Commun. 2025 Jan 6;7(1):fcae478. doi: 10.1093/braincomms/fcae478. eCollection 2025.
6
Space exploration and risk of Parkinson's disease: a perspective review.太空探索与帕金森病风险：一篇综述
NPJ Microgravity. 2025 Jan 3;11(1):1. doi: 10.1038/s41526-024-00457-6.
7
Safety, Tolerability and Pharmacokinetic-Pharmacodynamic Relationship of NX210c Peptide in Healthy Elderly Volunteers: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascending Dose Study.NX210c肽在健康老年志愿者中的安全性、耐受性及药代动力学-药效学关系：随机、安慰剂对照、双盲、多次递增剂量研究
Neurol Ther. 2025 Feb;14(1):357-377. doi: 10.1007/s40120-024-00691-w. Epub 2024 Dec 21.
8
Exploring the causal link between serum amino acids and Parkinson's disease: a Mendelian randomization approach.探索血清氨基酸与帕金森病之间的因果关系：孟德尔随机化方法
Sci Rep. 2024 Dec 4;14(1):30271. doi: 10.1038/s41598-024-81787-z.
9
Homocysteine, neurodegenerative biomarkers, and APOE ε4 in neurodegenerative diseases.同型半胱氨酸、神经退行性生物标志物与载脂蛋白E ε4在神经退行性疾病中的作用
Alzheimers Dement. 2025 Jan;21(1):e14376. doi: 10.1002/alz.14376. Epub 2024 Nov 19.
10
Association analysis of MTHFR (rs1801133 and rs1801131) gene polymorphism towards the development of type 2 diabetes mellitus in Dali area population from Yunnan Province, China.中国云南省大理地区人群中 MTHFR（rs1801133 和 rs1801131）基因多态性与 2 型糖尿病发病的关联分析。
PeerJ. 2024 Oct 24;12:e18334. doi: 10.7717/peerj.18334. eCollection 2024.
本文引用的文献
1
Hydrolysis of homocysteine thiolactone results in the formation of Protein-Cys-S-S-homocysteinylation.同型半胱氨酸硫内酯的水解导致蛋白质半胱氨酸巯基亚砜同型半胱氨酸化。
Proteins. 2019 Aug;87(8):625-634. doi: 10.1002/prot.25681. Epub 2019 Apr 15.
2
Disturbed homocysteine metabolism is associated with cancer.同型半胱氨酸代谢紊乱与癌症有关。
Exp Mol Med. 2019 Feb 21;51(2):1-13. doi: 10.1038/s12276-019-0216-4.
3
Melatonin protects against behavioral deficits, dopamine loss and oxidative stress in homocysteine model of Parkinson's disease.褪黑素可预防帕金森病同型半胱氨酸模型中的行为缺陷、多巴胺丧失及氧化应激。
Life Sci. 2018 Jan 1;192:238-245. doi: 10.1016/j.lfs.2017.11.016. Epub 2017 Nov 11.
4
The role of methionine on metabolism, oxidative stress, and diseases.蛋氨酸在代谢、氧化应激和疾病中的作用。
Amino Acids. 2017 Dec;49(12):2091-2098. doi: 10.1007/s00726-017-2494-2. Epub 2017 Sep 19.
5
Homocysteine and cognitive function in Parkinson's disease.同型半胱氨酸与帕金森病认知功能。
Parkinsonism Relat Disord. 2017 Nov;44:1-5. doi: 10.1016/j.parkreldis.2017.08.005. Epub 2017 Aug 9.
6
Epidemiology of Parkinson's disease.帕金森病的流行病学
J Neural Transm (Vienna). 2017 Aug;124(8):901-905. doi: 10.1007/s00702-017-1686-y. Epub 2017 Feb 1.
7
Testing for homocysteine in clinical practice.临床实践中的同型半胱氨酸检测。
Nutr Health. 2017 Mar;23(1):13-15. doi: 10.1177/0260106016686094. Epub 2017 Jan 10.
8
Hyperhomocysteinemia results from and promotes hepatocellular carcinoma via CYP450 metabolism by CYP2J2 DNA methylation.高同型半胱氨酸血症通过CYP2J2 DNA甲基化介导的CYP450代谢产生并促进肝细胞癌。
Oncotarget. 2017 Feb 28;8(9):15377-15392. doi: 10.18632/oncotarget.14165.
9
The Molecular and Cellular Effect of Homocysteine Metabolism Imbalance on Human Health.同型半胱氨酸代谢失衡对人类健康的分子和细胞影响。
Int J Mol Sci. 2016 Oct 20;17(10):1733. doi: 10.3390/ijms17101733.
10
Oxidative stress and mitochondrial dysfunction are the underlying events of dopaminergic neurodegeneration in homocysteine rat model of Parkinson's disease.氧化应激和线粒体功能障碍是帕金森病同型半胱氨酸大鼠模型中多巴胺能神经变性的潜在事件。
Neurochem Int. 2016 Dec;101:48-55. doi: 10.1016/j.neuint.2016.10.001. Epub 2016 Oct 11.
Zotero 插件