Johnson Gemma, Ferrini Arianna, Dolan Stephen K, Nolan Tania, Agrawal Samir, Doyle Sean, Bustin Stephen A
Blizard Institute, Queen Mary University of London, London, UK.
Biomark Med. 2014;8(3):429-51. doi: 10.2217/bmm.13.129.
The incidence of invasive aspergillosis (IA), an opportunistic infection in immunocompromised individuals, is rising, but its early diagnosis remains challenging and treatment options are limited. Hence there is an urgent need to improve existing diagnostic procedures as well as develop novel approaches. The clinical usefulness of galactomannan and β-d-glucan, widely used assays detecting cell-wall antigens of Aspergillus, is unclear and depends on clinicians' awareness of their practical limitations. This leaves room for new methods that utilise genomic, proteomic and metabolomics approaches as well as novel detection procedures, for example point-of-care lateral-flow devices. Each of these strategies has its own limitations and it is likely that a combination of methods will be required to achieve optimal performance for the diagnosis of IA and subsequent appropriate patient management.
侵袭性曲霉病（IA）是免疫功能低下个体中的一种机会性感染，其发病率正在上升，但其早期诊断仍然具有挑战性，治疗选择也有限。因此，迫切需要改进现有的诊断程序并开发新方法。广泛用于检测曲霉细胞壁抗原的半乳甘露聚糖和β -d-葡聚糖检测方法的临床实用性尚不清楚，并且取决于临床医生对其实际局限性的认识。这为利用基因组学、蛋白质组学和代谢组学方法以及新型检测程序（例如即时检测侧向流动装置）的新方法留出了空间。这些策略中的每一种都有其自身的局限性，并且可能需要结合多种方法才能实现IA诊断的最佳性能以及随后对患者的适当管理。
