Singleton Michael D, Sanderson Wayne T, Mannino David M
Department of Epidemiology, University of Kentucky College of Public Health , Lexington, KY , USA .
J Asthma. 2014 Sep;51(7):756-61. doi: 10.3109/02770903.2014.912302. Epub 2014 May 15.
Increases in asthma and obesity over the past three decades have led to speculation about a causal link between the two diseases. However, investigations of the relationship between body mass index (BMI) and fractional exhaled nitric oxide (FeNO) - a marker of eosinophilic airway inflammation - have produced mixed results. The purpose of this study was to evaluate the relationship between body mass index (BMI), asthma and FeNO in a sample of U.S. adults using data from the National Health and Nutrition Examination Surveys (NHANES) for 2007-2010.
We assessed the relationship between FeNO and BMI in subjects with and without asthma using categorical and continuous models for BMI. All models controlled for age, gender, ethnicity, household income-to-poverty ratio, atopy and current smoking.
Adjusted asthma prevalence was positively associated with BMI, and subjects with asthma had higher adjusted FeNO levels than subjects without asthma. However, no association between FeNO and BMI was observed in either those with (β = 0.002, p = 0.74) or without (β = 0.0014, p = 0.51) asthma after adjusting for covariates.
Our results suggest that in the U.S. adult population, BMI is not associated with eosinophilic airway inflammation.
在过去三十年中，哮喘和肥胖症的发病率不断上升，引发了人们对这两种疾病之间因果关系的猜测。然而，对体重指数（BMI）与呼出一氧化氮分数（FeNO）——一种嗜酸性气道炎症标志物——之间关系的研究结果却喜忧参半。本研究的目的是利用2007 - 2010年美国国家健康与营养检查调查（NHANES）的数据，评估美国成年人样本中体重指数（BMI）、哮喘与FeNO之间的关系。
我们使用BMI的分类和连续模型，评估了患有和未患有哮喘的受试者中FeNO与BMI之间的关系。所有模型均对年龄、性别、种族、家庭收入与贫困率、特应性和当前吸烟情况进行了控制。
调整后的哮喘患病率与BMI呈正相关，患有哮喘的受试者调整后的FeNO水平高于未患哮喘的受试者。然而，在调整协变量后，无论是患有哮喘的受试者（β = 0.002，p = 0.74）还是未患哮喘的受试者（β = 0.0014，p = 0.51），均未观察到FeNO与BMI之间存在关联。
我们的结果表明，在美国成年人群中，BMI与嗜酸性气道炎症无关。
