Zhang Haoyu, Hu Zhigang, Wang Sufei, Xu Jiangli, Li Sijia, Song Xinyu
Department of Respiratory and Critical Care Medicine, The First College of Clinical Medicine Science, China Three Gorges University, Yichang, China.
Department of Respiratory and Critical Care Medicine, Yichang Central People's Hospital, Yichang, China.
Front Physiol. 2023 Feb 10;14:1019123. doi: 10.3389/fphys.2023.1019123. eCollection 2023.
Obesity is considered a risk factor for asthma exacerbation. However, limited studies have focused on the association of different levels of weight clusters with asthma. As such, we study the associations between different weight clusters with FeNO, blood eosinophils, and lung function among adult asthmatics. Data from 789 participants aged 20 years or older in the National Health and Nutrition Examination Survey 2007-2012 were analyzed. Body mass index (BMI) and waist circumference (WC) were used to determine the weight status. The study population was divided into five groups, including normal weight and low WC (153), normal weight and high WC (43), overweight and high WC (67), overweight and abdominal obesity (128), and general and abdominal obesity (398). A Multivariate linear regression model was used to evaluate the abovementioned associations after adjusting for potential confounding factors. The adjusted models showed that general and abdominal obesity cluster (adjusted β = -0.63, 95% confidence interval (CI): -1.08, -0.17 < 0.01), and the normal weight with high WC cluster (adjusted β = -0.96, 95% CI: -1.74, -0.19 < 0.05) were associated with lower levels of blood eosinophils percentage than normal weight and low WC cluster. A similar tendency was shown in the levels of FeNO, but the differences were not significant ( > 0.05). Furthermore, abdominal obesity clusters were significantly associated with lower FVC, FVC% predicted, and FEV measures than normal weight and low WC cluster, especially those individuals with general and abdominal obesity cluster. No association was found between different weight clusters and FEV/FVCF ratio. The two other weight clusters did not show the association with any of the lung function measures. General and abdominal obesity were associated with lung function impairment and a significant reduction of FeNO and blood eosinophil percentage. This study emphasized the importance of concurrent determination of BMI and WC in asthma clinical practice.
肥胖被认为是哮喘加重的一个危险因素。然而，针对不同体重组与哮喘之间关联的研究有限。因此，我们研究了成年哮喘患者中不同体重组与呼出一氧化氮（FeNO）、血液嗜酸性粒细胞和肺功能之间的关联。分析了2007 - 2012年美国国家健康与营养检查调查中789名年龄在20岁及以上参与者的数据。使用体重指数（BMI）和腰围（WC）来确定体重状况。研究人群分为五组，包括正常体重且低腰围（153人）、正常体重且高腰围（43人）、超重且高腰围（67人）、超重且腹型肥胖（128人）以及全身肥胖且腹型肥胖（398人）。在调整潜在混杂因素后，使用多元线性回归模型评估上述关联。调整后的模型显示，全身肥胖且腹型肥胖组（调整后的β = -0.63，95%置信区间（CI）：-1.08，-0.17，P < 0.01）以及正常体重且高腰围组（调整后的β = -0.96，95% CI：-1.74，-0.19，P < 0.05）与正常体重且低腰围组相比，血液嗜酸性粒细胞百分比水平较低。FeNO水平也呈现类似趋势，但差异不显著（P > 0.05）。此外，腹型肥胖组与正常体重且低腰围组相比，用力肺活量（FVC）、预测FVC%以及第一秒用力呼气容积（FEV）测量值显著降低，尤其是全身肥胖且腹型肥胖组的个体。不同体重组与FEV/FVC比值之间未发现关联。其他两个体重组与任何肺功能测量指标均未显示出关联。全身肥胖且腹型肥胖与肺功能损害以及FeNO和血液嗜酸性粒细胞百分比的显著降低有关。本研究强调了在哮喘临床实践中同时测定BMI和WC的重要性。
