Mosin V I, Budagov N M
Ter Arkh. 1989;61(2):11-5.
The content of pancreatic enzymes, cyclic nucleotides and prostaglandins (PG) in the duodenal contents was measured in 77 patients with chronic pancreatitis and in 20 healthy individuals. Pancreatitis exacerbation was attended by a decrease in enzymatic activity, in bicarbonate, cAMP and cGMP production. The content of PGE in pancreatic secretion remained normal, that of PGF2 alpha was elevated. Stimulation of the exocrine part of the pancreas by means of euphylline, pentagastrin and calcium was accompanied by the rise of the content of cyclic nucleotides rather than of PG. Suppression of enzymatic secretion by contrykal was followed by the reduction in the content of the cyclic nucleotides and PGE. The data suggest that cyclic nucleotides and PG are involved in the mechanism by which the external secretion of the pancreas is impaired in patients with chronic pancreatitis.
对77例慢性胰腺炎患者和20名健康个体的十二指肠内容物中的胰腺酶、环核苷酸和前列腺素（PG）含量进行了测定。胰腺炎发作时，酶活性、碳酸氢盐、cAMP和cGMP生成减少。胰腺分泌中PGE的含量保持正常，PGF2α的含量升高。通过氨茶碱、五肽胃泌素和钙刺激胰腺外分泌部时，环核苷酸含量升高，而非PG含量升高。抑肽酶抑制酶分泌后，环核苷酸和PGE含量降低。数据表明，环核苷酸和PG参与了慢性胰腺炎患者胰腺外分泌受损的机制。
