Elizarova S S, Lebedev N N
Biull Eksp Biol Med. 1978 Sep;86(9):289-92.
In acute experiments on dogs with preliminarily induced pancreatitis the authors traced disturbances of the secretory reactions of the pancreas in response to adequate stimulation with the intestinal hormones. There was a reduction in the activity of complex intestinal hormones preparations obtained from the duodenal mucosa at the acute period of the disease in these dogs. In chronic experiments there was found an increase of acid production debit in the stomach and a shift in the duodenal contents reaction in the acid direction in pancreatitis. A conclusion was drawn on an important pathogenetic role played by the intestinal hormones in the mechanism of disturbances of the pancreatic exocrine secretion in pancreatitis.
在对预先诱发胰腺炎的狗进行的急性实验中，作者追踪了胰腺在受到肠激素充分刺激时分泌反应的紊乱情况。在这些狗患病急性期，从十二指肠黏膜获得的复合肠激素制剂的活性降低。在慢性实验中，发现胰腺炎时胃内酸分泌量增加，十二指肠内容物反应向酸性方向转变。得出的结论是，肠激素在胰腺炎胰腺外分泌分泌紊乱机制中起重要的致病作用。
