通过光氧化还原催化实现α-氨基酸的脱羧芳基化：生物质向药物药效基团的一步转化。
Decarboxylative arylation of α-amino acids via photoredox catalysis: a one-step conversion of biomass to drug pharmacophore.
作者信息
Zuo Zhiwei, MacMillan David W C
机构信息
Merck Center for Catalysis, Princeton University , Princeton, New Jersey 08544, United States.
出版信息
J Am Chem Soc. 2014 Apr 9;136(14):5257-60. doi: 10.1021/ja501621q. Epub 2014 Mar 31.
Abstract
The direct decarboxylative arylation of α-amino acids has been achieved via visible light-mediated photoredox catalysis. This method offers rapid entry to prevalent benzylic amine architectures from an abundant biomass, specifically α-amino acid precursors. Significant substrate scope is observed with respect to both the amino acid and arene components.
摘要
通过可见光介导的光氧化还原催化实现了α-氨基酸的直接脱羧芳基化反应。该方法能够从丰富的生物质（特别是α-氨基酸前体）快速构建常见的苄胺结构。在氨基酸和芳烃组分方面都观察到了显著的底物范围。
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