醋酸格拉替雷通过诱导海马神经发生逆转颅照射大鼠的认知缺陷。
Glatiramer acetate reverses cognitive deficits from cranial-irradiated rat by inducing hippocampal neurogenesis.
机构信息
State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People's Republic of China; Department of Radiation Oncology, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, People's Republic of China.
Department of Anatomy and Neurobiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China.
出版信息
J Neuroimmunol. 2014 Jun 15;271(1-2):1-7. doi: 10.1016/j.jneuroim.2014.03.015. Epub 2014 Mar 26.
Patients received cranial-irradiation can be affected with cognitive deficits and decreasing hippocampal neurogenesis. In this work, we characterized the cognitive ability and immune-induced neurogenesis of the pre- and post-treated cranial-irradiated rats with Glatiramer acetate (GA), known as a weak CNS auto-antigen. The GA-treated rats displayed better cognitive abilities in Morris water maze (MWM). The numbers of Iba-I-positive microglia, BrdU(+)/DCX(+) cells and BrdU(+)/NeuN(+) cells in hippocampus increased, which are accompanied with increased IFN-γ and decreased IL-6, IL-4. Furthermore, GA reverted the Th1/Th2 balance. GA treatment can reverse the cognitive deficits caused by cranial irradiation through a mechanism that likely involves immunomodulation.
接受颅脑放射治疗的患者可能会出现认知缺陷和海马神经发生减少。在这项工作中，我们描述了用已知的弱中枢神经系统自身抗原——醋酸格拉替雷（GA）处理的颅脑照射前和照射后的大鼠的认知能力和免疫诱导的神经发生。GA 处理的大鼠在 Morris 水迷宫（MWM）中表现出更好的认知能力。海马内的 Iba-1 阳性小胶质细胞、BrdU(+)/DCX(+)细胞和 BrdU(+)/NeuN(+)细胞数量增加，同时 IFN-γ 增加，IL-6、IL-4 减少。此外，GA 逆转了 Th1/Th2 平衡。GA 治疗可以通过一种可能涉及免疫调节的机制逆转颅脑照射引起的认知缺陷。
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