Department of Neurology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Norwegian Multiple Sclerosis Registry and Biobank, Department of Neurology, Haukeland University Hospital, Bergen, Norway; KG Jebsen MS Research Centre, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
J Neuroimmunol. 2014 Jun 15;271(1-2):60-5. doi: 10.1016/j.jneuroim.2014.03.014. Epub 2014 Mar 24.
To explore the relationships between vitamin A, D and E and inflammation in relapsing remitting multiple sclerosis, we assessed their associations with 11 inflammation markers in 9 serial serum samples from 85 patients, before and during interferon-β1a treatment. A negative association was found between vitamin A and pentraxin 3 independent of interferon-β1a use, whereas positive associations between vitamin D and interleukin-1 receptor antagonist and secreted frizzled-related protein 3 were seen before, and between vitamin E and chemokine (C-X-C motif) ligand 16 during interferon-β1a treatment. These findings suggest associations with diverse inflammatory pathways, which may be differentially influenced by interferon-β1a treatment.
为了探究维生素 A、D 和 E 与复发性缓解型多发性硬化症中的炎症之间的关系，我们评估了它们与 85 名患者的 9 个连续血清样本中的 11 个炎症标志物之间的关联，这些患者在接受干扰素-β1a 治疗前后均接受了评估。结果发现，维生素 A 与 pentraxin 3 之间存在负相关，与干扰素-β1a 的使用无关，而维生素 D 与白细胞介素-1 受体拮抗剂和分泌卷曲相关蛋白 3 之间存在正相关，维生素 E 与干扰素-β1a 治疗期间的趋化因子（C-X-C 基序）配体 16 之间存在正相关。这些发现表明与多种炎症途径有关，这些途径可能受到干扰素-β1a 治疗的不同影响。
