Trapet Pauline, Kulik Anna, Lamotte Olivier, Jeandroz Sylvain, Bourque Stéphane, Nicolas-Francès Valérie, Rosnoblet Claire, Besson-Bard Angélique, Wendehenne David
Université de Bourgogne, UMR 1347 Agroécologie, BP 86510, F-21000 Dijon, France; ERL CNRS 6300, BP 86510, 21000 Dijon, France.
INRA, UMR 1347 Agroécologie, BP 86510, F-21000 Dijon, France; ERL CNRS 6300, BP 86510, 21000 Dijon, France.
Phytochemistry. 2015 Apr;112:72-9. doi: 10.1016/j.phytochem.2014.03.015. Epub 2014 Apr 5.
Nitric oxide (NO) is a free radical gas involved in a myriad of plant physiological processes including immune responses. How NO mediates its biological effects in plant facing microbial pathogen attack is an unresolved question. Insights into the molecular mechanisms by which it propagates signals reveal the contribution of this simple gas in complex signaling pathways shared with reactive oxygen species (ROS) and the second messenger Ca(2+). Understanding of the subtle cross-talks operating between these signals was greatly improved by the recent identification and the functional analysis of proteins regulated through S-nitrosylation, a major NO-dependent post-translational protein modification. Overall, these findings suggest that NO is probably an important component of the mechanism coordinating and regulating Ca(2+) and ROS signaling in plant immunity.
一氧化氮（NO）是一种自由基气体，参与包括免疫反应在内的众多植物生理过程。在面对微生物病原体攻击时，NO如何介导其在植物中的生物学效应仍是一个未解决的问题。对其信号传导分子机制的深入了解揭示了这种简单气体在与活性氧（ROS）和第二信使Ca(2+)共享的复杂信号通路中的作用。通过最近对通过S-亚硝基化调节的蛋白质的鉴定和功能分析，对这些信号之间微妙的相互作用的理解有了很大的提高，S-亚硝基化是一种主要的NO依赖性蛋白质翻译后修饰。总体而言，这些发现表明，NO可能是植物免疫中协调和调节Ca(2+)和ROS信号传导机制的重要组成部分。
