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炎症性肠病患者脂质异常概述

An overview of lipid abnormalities in patients with inflammatory bowel disease.

作者信息

Agouridis Aris P, Elisaf Moses, Milionis Haralampos J

机构信息

Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece.

出版信息

Ann Gastroenterol. 2011;24(3):181-187.

PMID:24713706
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3959314/
Abstract

INFLAMMATORY BOWEL DISEASE (IBD) IS A CHRONIC INFLAMMATORY DISORDER WHICH ENCOMPASSES TWO FORMS OF INTESTINAL INFLAMMATION: ulcerative colitis and Crohn's disease. It is reported that inflammation, carotid intima media thickness, homocysteine and insulin resistance, parameters that are all associated with atherosclerosis, are increased in IBD. On the contrary, it seems that IBD patients exhibit low levels of low density lipoprotein cholesterol and total cholesterol. This review highlights the lipid profiles that occur in IBD patients and summarizes data of studies using regimens that may affect lipid metabolism in these patients.

摘要

炎症性肠病(IBD)是一种慢性炎症性疾病,包括两种肠道炎症形式:溃疡性结肠炎和克罗恩病。据报道,炎症、颈动脉内膜中层厚度、同型半胱氨酸和胰岛素抵抗(这些参数均与动脉粥样硬化相关)在IBD患者中有所增加。相反,IBD患者似乎低密度脂蛋白胆固醇和总胆固醇水平较低。本综述重点介绍了IBD患者的血脂情况,并总结了使用可能影响这些患者脂质代谢的治疗方案的研究数据。

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本文引用的文献

1
Prevalence and epidemiology of overweight and obesity in children with inflammatory bowel disease.炎症性肠病患儿超重和肥胖的流行率和流行病学。
Inflamm Bowel Dis. 2011 Oct;17(10):2162-8. doi: 10.1002/ibd.21585. Epub 2010 Dec 17.
2
Risk of colorectal cancer in self-reported inflammatory bowel disease and modification of risk by statin and NSAID use.自报的炎症性肠病患者罹患结直肠癌的风险,以及他汀类药物和 NSAID 使用对风险的影响。
Cancer. 2011 Apr 15;117(8):1640-8. doi: 10.1002/cncr.25731. Epub 2010 Nov 8.
3
Dyslipidemia and lipoprotein profiles in patients with inflammatory bowel disease.炎症性肠病患者的血脂异常和脂蛋白谱。
J Clin Lipidol. 2010 Nov-Dec;4(6):478-82. doi: 10.1016/j.jacl.2010.08.021. Epub 2010 Oct 28.
4
Leptin and adiponectin levels in patients with ankylosing spondylitis. The effect of infliximab treatment.血清瘦素和脂联素水平在强直性脊柱炎患者。英夫利昔单抗治疗的影响。
Clin Exp Rheumatol. 2010 Nov-Dec;28(6):880-3. Epub 2011 Jan 3.
5
Dietary n-3 polyunsaturated fatty acids and the aetiology of ulcerative colitis: a UK prospective cohort study.膳食 n-3 多不饱和脂肪酸与溃疡性结肠炎发病机制的关系:英国前瞻性队列研究。
Eur J Gastroenterol Hepatol. 2010 May;22(5):602-6. doi: 10.1097/MEG.0b013e3283352d05.
6
Inflammatory bowel disease: review from the aspect of genetics.炎症性肠病:从遗传学角度的综述。
J Gastroenterol. 2009;44(11):1097-108. doi: 10.1007/s00535-009-0141-8.
7
Omega-3 polyunsaturated fatty acids and cardiovascular diseases.欧米伽-3多不饱和脂肪酸与心血管疾病
J Am Coll Cardiol. 2009 Aug 11;54(7):585-94. doi: 10.1016/j.jacc.2009.02.084.
8
The acute (cerebro)vascular effects of statins.他汀类药物的急性(脑血管)效应。
Anesth Analg. 2009 Aug;109(2):572-84. doi: 10.1213/ane.0b013e3181a85d0e.
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The JUPITER trial: How will it change clinical practice?JUPITER试验:它将如何改变临床实践?
Rev Cardiovasc Med. 2009 Spring;10(2):91-6.
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The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials.他汀类药物对无心血管疾病但有心血管危险因素人群的益处:随机对照试验的荟萃分析。
BMJ. 2009 Jun 30;338:b2376. doi: 10.1136/bmj.b2376.