Korkmaz Huseyin, Sahin Fatih, Ipekci Suleyman H, Temel Tuncer, Kebapcilar Levent
aDepartment of Internal Medicine, Division of Gastroenterology bDepartment of Internal Medicine, Division of Endocrinology and Metabolism, Faculty of Medicine, Selcuk University, Konya cDepartment of Internal Medicine, Division of Gastroenterology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey.
Eur J Gastroenterol Hepatol. 2014 Jul;26(7):725-32. doi: 10.1097/MEG.0000000000000104.
Both ulcerative colitis and Crohn's disease are forms of inflammatory bowel disease (IBD), which is characterized by chronic, progressive inflammation of the gastrointestinal tract. Recent studies have shed new light on the importance of inflammation in the pathogenesis of arterial stiffness.
This study aimed to evaluate the relationship between pulse wave velocity (PWV) measurement and biochemical parameters in inactive and active IBD patients without cardiovascular risk factors and perform a comparison with the control group.
We enrolled 102 IBD patients without cardiovascular risk factors and 74 matched controls, and evaluated each patient in active and inactive disease periods. All patients completed a standard questionnaire form and we assessed various laboratory parameters. We carried out vascular measurements using a Mobil-O-Graph 24-h pulse wave analysis monitor, an automatic oscillometric device.
Although cardiovascular risk factors, such as total cholesterol and low-density lipoprotein cholesterol, were significantly lower (P<0.05) in IBD patients than the controls, 24 h, day and night PWV values, erythrocyte sedimentation rate, C-reactive protein, insulin, homeostasis model assessment of insulin resistance, and homocysteine were higher in patients with active and inactive IBD than the controls (P<0.05). Multiple linear regression analysis showed that PWV was correlated positively with age and duration of IBD.
This study showed increased PWV, homocysteine, erythrocyte sedimentation rate, C-reactive protein, insulin, and homeostasis model assessment of insulin resistance in patients with active and inactive IBD and provides evidence of the potential contribution of inflammation and inflammation-related factors toward arterial stiffening independent from conventional cardiovascular risk factors.
溃疡性结肠炎和克罗恩病均为炎症性肠病（IBD）的表现形式，其特征为胃肠道的慢性进行性炎症。最近的研究为炎症在动脉僵硬度发病机制中的重要性提供了新的线索。
本研究旨在评估无心血管危险因素的活动期和非活动期IBD患者的脉搏波速度（PWV）测量值与生化参数之间的关系，并与对照组进行比较。
我们纳入了102例无心血管危险因素的IBD患者和74例匹配的对照组，并在疾病的活动期和非活动期对每位患者进行评估。所有患者均完成一份标准问卷，我们评估了各种实验室参数。我们使用Mobil-O-Graph 24小时脉搏波分析监测仪（一种自动示波装置）进行血管测量。
尽管IBD患者的总胆固醇和低密度脂蛋白胆固醇等心血管危险因素显著低于对照组（P<0.05），但活动期和非活动期IBD患者的24小时、白天和夜间PWV值、红细胞沉降率、C反应蛋白、胰岛素、胰岛素抵抗的稳态模型评估以及同型半胱氨酸均高于对照组（P<0.05）。多元线性回归分析显示，PWV与年龄和IBD病程呈正相关。
本研究表明，活动期和非活动期IBD患者的PWV、同型半胱氨酸、红细胞沉降率、C反应蛋白、胰岛素以及胰岛素抵抗的稳态模型评估均升高，并提供了炎症和炎症相关因素对动脉僵硬度的潜在影响独立于传统心血管危险因素的证据。
