Unit of Anatomical Pathology, Cordoba University Medical School, Faculty of Medicine, E-14004, Cordoba, Spain;
Am J Clin Pathol. 2014 May;141(5):747-52. doi: 10.1309/AJCPM86FVHAMWJSR.
To investigate primary osteosarcoma (osteogenic sarcoma) of the kidney, a rare and aggressive neoplasm.
We present clinical and pathologic features of three female patients, aged 50, 66, and 78 years, affected by primary osteosarcoma of the kidney. The diagnosis was made by H&E-stained samples from totally (cases 1 and 2) or partially (case 3) embedded tumors.
Reported cases showed histologic features of low-grade (n = 1), chondroblastic (n = 1), and osteoblastic (n = 1) osteosarcoma. Tumor size ranged from 3 to 7 cm, and pT category was pT1a (n = 1), pT1b (n = 1), and pT3a (n = 1). Immunohistochemistry gave focal positive results with PAX2 and CD10 in case 1 and S100 in case 2. On follow-up, two patients were disease free at 25 and 68 months and one died of metastases.
Surgically treated primary renal osteosarcoma might not be as aggressive as previously thought if diagnosed early with low pT status.
研究肾脏原发性骨肉瘤（成骨肉瘤），这是一种罕见且侵袭性的肿瘤。
我们介绍了 3 名女性患者的临床和病理特征，年龄分别为 50 岁、66 岁和 78 岁，均患有肾脏原发性骨肉瘤。诊断是通过对完全（病例 1 和 2）或部分（病例 3）嵌入肿瘤的 H&E 染色样本进行的。
报告的病例显示出低级别（n=1）、软骨母细胞样（n=1）和成骨细胞样（n=1）骨肉瘤的组织学特征。肿瘤大小从 3 厘米到 7 厘米不等，pT 分期为 pT1a（n=1）、pT1b（n=1）和 pT3a（n=1）。免疫组化显示病例 1 中 PAX2 和 CD10 呈局灶阳性，病例 2 中 S100 呈阳性。随访时，2 名患者无疾病存活 25 个月和 68 个月，1 名患者因转移而死亡。
如果早期诊断为低 pT 状态，手术治疗的肾脏原发性骨肉瘤可能不像以前认为的那样具有侵袭性。
