Second Ward of Bone and Soft Tissue Tumor Surgery, Cancer Hospital of Dalian University of Technology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, Liaoning, 110042, China.
The Liaoning Provincial Key Laboratory of Interdisciplinary Research on Gastrointestinal Tumor Combining Medicine with Engineering, Shenyang, Liaoning, 110042, China.
Mol Cancer. 2024 Nov 1;23(1):246. doi: 10.1186/s12943-024-02161-1.
Malignant bone tumors, which are difficult to treat with current clinical strategies, originate from bone tissues and can be classified into primary and secondary types. Due to the specificity of the bone microenvironment, the results of traditional means of treating bone tumors are often unsatisfactory, so there is an urgent need to develop new treatments for malignant bone tumors. Recently, nanoparticle-based approaches have shown great potential in diagnosis and treatment. Nanoparticles (NPs) have gained significant attention due to their versatility, making them highly suitable for applications in bone tissue engineering, advanced imaging techniques, and targeted drug delivery. For diagnosis, NPs enhance imaging contrast and sensitivity by integrating targeting ligands, which significantly improve the specific recognition and localization of tumor cells for early detection. For treatment, NPs enable targeted drug delivery, increasing drug accumulation at tumor sites while reducing systemic toxicity. In conclusion, understanding bone microenvironment and using the unique properties of NPs holds great promise in improving disease management, enhancing treatment outcomes, and ultimately improving the quality of life for patients with malignant bone tumors. Further research and development will undoubtedly contribute to the advancement of personalized medicine in the field of bone oncology.
恶性骨肿瘤是一种难以用现有临床策略治疗的疾病，起源于骨组织，可以分为原发性和继发性两种类型。由于骨微环境的特殊性，传统的骨肿瘤治疗方法往往效果不佳，因此迫切需要开发治疗恶性骨肿瘤的新方法。最近，基于纳米粒子的方法在诊断和治疗方面显示出巨大的潜力。由于其多功能性，纳米粒子（NPs）引起了广泛关注，非常适合应用于骨组织工程、先进的成像技术和靶向药物输送。在诊断方面，纳米粒子通过整合靶向配体来增强成像对比度和灵敏度，从而显著提高肿瘤细胞的特异性识别和定位，实现早期检测。在治疗方面，纳米粒子能够实现靶向药物输送，增加药物在肿瘤部位的积累，同时降低全身毒性。总之，了解骨微环境并利用纳米粒子的独特性质有望改善疾病管理，提高治疗效果，最终提高恶性骨肿瘤患者的生活质量。进一步的研究和开发无疑将有助于推进骨肿瘤学领域的个性化医学。
